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Distinct patterns of atrial electrical and structural remodeling in angiotensin II mediated atrial fibrillation.
Atrial fibrillation (AF) is prevalent in hypertension and elevated angiotensin II (Ang II); however, the mechanisms by which Ang II leads to AF are poorly understood. Here, we investigated the basis for this in mice treated with Ang II or saline for 3 …
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Free-hand ultrasound guidance permits safe and efficient minimally invasive intrathymic injections in both young and aged mice
The goal of this study was to evaluate whether use of an aseptic free-hand approach to ultrasound-guided injection facilitates injection into the thymic gland in mice. We used this interventional radiology technique in young, aged and immunodeficient mice …
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An alternative method for intrathymic injections in mice
The thymus is a bi-lobed lymphatic organ located in the anterior portion of the ventral thoracic cavity, just behind the sternum. Because the thymus is the site of development of T lymphocytes (T cells), it is frequently targeted in research studies that …
Publication
Wulff in a cage gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging
A core–shell nanostructure yields balanced contrast production for both CT and photoacoustics. …
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Ultrasound-guided spectral photoacoustic imaging of hemoglobin oxygenation during development
Few technologies are capable of imaging in vivo function during development. In this study, we have implemented spectral photoacoustic imaging to estimate tissue oxygenation longitudinally in pregnant mice. We used the spectral photoacoustic signal to …
Publication
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
Oxidative stress plays an important role in the pathogenesis of many disease states. In the heart, reactive oxygen species are linked with cardiac ischemia/reperfusion injury, hypertrophy, and heart failure. While this correlation between ROS and cardiac …
Publication
Curcumin protects against diabetic cardiomyopathy by promoting autophagy and alleviating apoptosis
The effects of curcumin on regulating cardiac apoptosis and autophagy were analyzed in diabetic models both in vivo and in vitro. In vivo, experimental diabetes was induced in mice by low-dose STZ injection combined with a high-fat diet. In vitro, …
Publication
Cardiac fibrosis in proteotoxic cardiac disease is dependent upon myofibroblast TGF-β signaling
Background-—Transforming growth factor beta (TGF-b) is an important cytokine in mediating the cardiac fibrosis that often accompanies pathogenic cardiac remodeling. Cardiomyocyte-specific expression of a mutant aB-crystallin (CryABR120G), which causes …
Publication
Lactobacillus supplementation prevents cisplatin-induced cardiotoxicity possibly by inflammation inhibition
Purpose Cardiotoxicity of chemotherapy exerts as the main hurdle for prognosis, while whether cisplatin causes severe cardiotoxicity remains largely unknown. Accumulating evidence reveals that intestinal microbiota functions importantly in nutrient …
Publication
The LKB1–AMPK-1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria
Hypoxic pulmonary vasoconstriction (HPV), which aids ventilation-perfusion matching in the lungs, is triggered by mechanisms intrinsic to pulmonary arterial smooth muscles. The unique sensitivity of these muscles to hypoxia is conferred by mitochondrial …