Cardiomyopathies are a leading cause of heart failure and are often caused by mutations in sarcomeric genes, resulting in contractile dysfunction and cellular damage. This may stimulate the production of a robust proin- flammatory response. To determine …

Molecularly-targeted microbubbles (MBs) are increasingly being recognized as promising contrast agents for oncological molecular imaging with ultrasound. With the detection and validation of new molecular imaging targets, novel binding ligands are needed …

PURPOSE: This preclinical study aimed to evaluate placental oxygenation in pregnant rats by real-time photoacoustic (PA) imaging on different days of gestation and to specify variations in placental oxygen saturation under conditions of maternal hypoxia …

Although high-frequency ultrasound imaging is gaining attention in various applications, hardly any ultrasound contrast agents (UCAs) dedicated to such frequencies (> 15 MHz) are available for contrast-enhanced ultrasound imaging (CEUS). Moreover, the …

Background Cardiac dysfunction is a severe complication of diabetes,with no effective treatment.Currently, bariatric surgery is moreandmorewidelyusedtoattenuate diabetes-associated diseases. The mechanism is not clear. Endoplasmic reticulum (ER) …

Mouse models of deep vein thrombosis …

Several erythropoietin-producing hepatocellular receptor B family (EPHB) and their ligands, ephrinBs (EFNBs), are involved in blood pressure regulation in animal models. We selected 528 single nucleotide polymorphisms (SNPs) within the genes of EPHB6, …

Background—Abdominal aortic aneurysms (AAAs) are a deadly pathology with strong sexual dimorphism. Similar to humans, female mice exhibit far lower incidences of angiotensin II (AngII)-induced AAAs than males. In addition to sex hormones, the X and Y sex …

Background: T2DM is a high-risk pregnancy with adverse fetal and maternal outcomes including repeated miscar- riages and fetal malformations. Despite the established association between placental insufficiency and poor mater- nal Th1-adaptability to the …

Doxorubicin (DOX) is an effective chemotherapeutic drug in the treatment of various types of cancers. However, its clinical application has been largely limited by potential development of cardiotoxicity. Previously we have shown that ultra-violet …