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Aggregate Enhanced Trimodal Porphyrin Shell Microbubbles for Ultrasound, Photoacoustic, and Fluorescence Imaging
Microbubbles (MBs) are currently used as ultrasound (US) contrast agents and as delivery vehicles for site-specific US-triggered drug and gene delivery. Multimodal US-based imaging methods have been applied preclinically to assess and validate the …
Publication
Handheld photoacoustic probe to detect both melanoma depth and volume at high speed in vivo
In the United States, Black infants have significantly worse birth outcomes than White infants. Over the past decades, public health efforts to address these disparities have focused primarily on increasing access to prenatal care, however, this has not …
Publication
In vivo Ultrasound and Photoacoustic Monitoring of Mesenchymal Stem Cells Labeled with Gold Nanotracers
Longitudinal monitoring of cells is required in order to understand the role of delivered stem cells in therapeutic neovascularization. However, there is not an imaging technique that is capable of quantitative, longitudinal assessment of stem cell …
Publication
What is new in nanoparticle-based photoacoustic imaging?
Photoacoustic imaging combines the high temporal and spatial resolution of ultrasound with the good contrast and spectral tuning of optical imaging. Contrast agents are used in photoacoustic imaging to further increase the contrast and specificity of …
Publication
Stable J-aggregation enabled dual photoacoustic and fluorescence nanoparticles for intraoperative cancer imaging
J-aggregates display nanoscale optical properties which enable their use in fluorescence and photo- acoustic imaging applications. However, control over their optical properties in an in vivo setting is ham- pered by the conformational lability of the …
Publication
Prediction of Tumor Recurrence and Therapy Monitoring Using Ultrasound-Guided Photoacoustic Imaging
Selection and design of individualized treatments remains a key goal in cancer therapeutics; prediction of response and tumor recurrence following a given therapy provides a basis for subsequent personalized treatment design. We demonstrate an approach …
Publication
A Spinal Cord Window Chamber Model for In Vivo Longitudinal Multimodal Optical and Acoustic Imaging in a Murine Model
In vivo and direct imaging of the murine spinal cord and its vasculature using multimodal (optical and acoustic) imaging techniques could significantly advance preclinical studies of the spinal cord. Such intrinsically high resolution and complementary …
Publication
A Facile, One-Step Nanocarbon Functionalization for Biomedical Applications
Despite their immense potential in biomedicine, carbon nanomaterials suffer from inefficient dispersion and biological activity in vivo. Here we utilize a single, yet multifunctional, hyaluronic acid-based biosurfactant to simultaneously disperse …
Publication
Photoacoustic imaging of angiogenesis in a subcutaneous islet transplant site in a murine model
Islet transplantation (IT) is an established clinical therapy for select patients with type-1 diabetes. Clinically, the hepatic portal vein serves as the site for IT. Despite numerous advances in clinical IT, limitations remain, including early islet cell …
Publication
2H,3H-Decafluoropentane-Based Nanodroplets: New Perspectives for Oxygen Delivery to Hypoxic Cutaneous Tissues
Perfluoropentane (PFP)-based oxygen-loaded nanobubbles (OLNBs) were previously pro- posed as adjuvant therapeutic tools for pathologies of different etiology sharing hypoxia as a common feature, including cancer, infection, and autoimmunity. Here we …