Search
Publication
VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice
The development of molecular probes and novel imaging modalities, allowing better resolution and specificity, is associated with an increased potential for molecular imaging of atherosclerotic plaques especially in basic and pre-clinical research …
Publication
Phototheranostic Porphyrin Nanoparticles Enable Visualization and Targeted Treatment of Head and Neck Cancer in Clinically Relevant Models
Head and neck cancer is the fifth most common type of cancer worldwide and remains challenging for effective treatment due to the proximity to critical anatomical structures in the head and neck region, which increases the probability of toxicity from …
Publication
In vitro and in vivo mapping of drug release after laser ablation thermal therapy with doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging
Doxorubicin-loaded hollow nanoshells (Dox@PEG-HAuNS) increases the efficacy of photothermal ablation (PTA) by not only mediating efficient PTA but also through chemotherapy, and therefore have potential utility for local anticancer therapy. However, in …
Publication
Porphyrin Nanodroplets: Sub-micrometer Ultrasound and Photoacoustic Contrast Imaging Agents
Ultrasound offers signifi cant potential as a molecular imaging modality when imaging microbubble agents owing to single-bubble sensitivity. However, these agents are typically too large to escape the vascular system. Photoacoustic imaging is a novel …
Publication
Ultrasound-guided photoacoustic imaging: current state and future development
Photoacoustic imaging, frequently coregistered with ultrasonic imaging, can provide functional and cellular/ molecular information about tissue within the anatomical land- marks of an imaged region. This review details the fundamen- tals of photoacoustic …
Publication
Functional Flow Patterns and Static Blood Pooling in Tumors Revealed by Combined Contrast-Enhanced Ultrasound and Photoacoustic Imaging
Alterations in tumor perfusion and microenvironment have been shown to be associated with aggressive cancer phenotypes, raising the need for noninvasive methods of tracking these changes. Dynamic contrast enhanced ultrasound (DCEUS) and photoacoustic (PA) …
Publication
Long circulating reduced graphene oxide–iron oxide nanoparticles for efficient tumor targeting and multimodality imaging
Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve the solubility of inorganic nanoparticles, prevent their aggregation and prolong their in vivo blood circulation half-life. Herein, we developed …
Publication
Label-free Detection of Lymph Node Metastases with US-guided Functional Photoacoustic Imaging
Summary: Photoacoustic imaging imparts the ability to distinguish materials according to their differences in optical absorp- tion (ie, their color) with the high spatial and temporal resolution of ultrasonography (US). Experiments in rats show the …
Publication
Design of hybrid MnO2-polymer-lipid nanoparticles with tunable oxygen generation rates and tumor accumulation for cancer treatment
Manganese dioxide (MnO 2 ) nanoparticles (NPs) were discovered in previous work to be effective in improving tumor oxygenation (hypoxia) and reducing H 2 O 2 and acidity in the tumor microenvironment (TME) via local injection. To develop MnO 2 …
Publication
Quantitative photoacoustic elastography in humans
Wereport quantitative photoacoustic elastography (QPAE) capable of measuring Young’s modulus of biological tissue in vivo in humans. By combining conventional PAE with a stress sensor having known stress– strain behavior, QPAE can simultaneously measure …