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Detection of Lung Tumor Progression in Mice by Ultrasound Imaging
With ~1.6 million victims per year, lung cancer contributes tremendously to the worldwide burden of cancer. Lung cancer is partly driven by genetic alterations in oncogenes such as the KRAS oncogene, which constitutes ~25% of lung cancer cases. The …
Publication
Low Intensity Focused Ultrasound Modulation of Vincristine Induced Neuropathy
Previously, we showed internal low intensity focused ultrasound (liFUS) improves nociceptive thresholds in rats with vincristine-induced neuropathy (VIN) for 48-h post-treatment. Here, we perform more rigorous behavioral testing with the internal device …
Publication
Bovine HDL and Dual Domain HDL-Mimetic Peptides Inhibit Tumor Develop- ment in Mice
A growing body of literature supports the role of apolipoproteins present in HDL in the treatment of pro-inflamma- tory diseases including cancer. We examined whether bovine HDL (bHDL) and three dual-domain peptides, namely AEM- 28 and its analog …
Publication
Surface-modified GVs as nanosized contrast agents for molecular ultrasound imaging of tumor
Nanobubbles, as a kind of new ultrasound contrast agent (UCAs), have shown promise to penetrate tumor vasculature to allow for targeted imaging. However, their inherent physical instability is an ongoing concern that could weaken their imaging ability …
Publication
Less is more: Silver-AIE core@shell nanoparticles for multimodality cancer imaging and synergistic therapy
Nanomaterials with integrated multiple imaging and therapeutic modalities possess great potentials in accurate cancer diagnostics and enhanced therapeutic efficacy. Traditional strategies for achieving multimodality nanoplatform through one by one …
Publication
Silica nanoparticles induce JNK-mediated inflammation and myocardial contractile dysfunction
Increasing environmental exposure to silica nanoparticles (SiNPs) and limited cardiotoxicity studies posed a challenge for the safety evaluation and management of these materials. This study aimed to explore the adverse effects and underlying mechanisms …
Publication
Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin
Background: Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts. This initially provides essential …
Publication
Prevention and rescue of cardiac dysfunction by methanocarba adenosine monophosphonate derivatives
Accumulating evidence supports a therapeutic role of purinergic signaling in cardiac diseases. Previously, efficacy of systemically infused MRS2339, a charged methanocarba derivative of 2-Cl-adenosine monophosphate, was demonstrated in animal models of …
Publication
Effects of external low intensity focused ultrasound on electrophysiological changes in vivo in a rodent model of common peroneal nerve injury
Non-invasive treatment methods for neuropathic pain are lacking. We assess how modulatory low intensity focused ultrasound (liFUS) at the L5 dorsal root ganglion (DRG) affects behavioral responses and sensory nerve action potentials (SNAPs) in a common …
Publication
Biodegradable theranostic nanoplatforms of albumin-biomineralized nanocomposites modified hollow mesoporous organosilica for photoacoustic imaging guided tumor synergistic therapy
Benefit from the integration of therapeutic and diagnostic functions, theranostic nanoplatforms have attracted widespread attention in preclinical research. Herein, a biodegradable theranostics nanoplatform based on hollow mesoporous organosilica …