Thermoneutral housing conditions cause rapid and reversible changes in mouse heart rate and blood pressure. Despite dramatic reductions in heart rate and blood pressure, thermoneutrality reduced the compensatory hypertrophic response in a pressure …

Systemic hypoxia is characterized by peripheral vasodilation and pulmonary vasoconstriction. However, the system-wide mechanism for signaling hypoxia remains unknown. Accumulating evidence suggests that hemoglobin (Hb) in RBCs may serve as an O2 sensor …

Vulnerable plaque rupture is the main trigger of most acute cardiovascular events. But the underlying mechanisms responsible for the transition from stable to vulnerable plaque remain largely unknown. Nuclear receptor subfamily 1 group D member 1 (NR1D1), …

Pathological hypertrophy underlies sudden cardiac death due to its high incidence of occurrence of ventricular arrhythmias. The alteration of transmural electrophysiological properties in hypertrophic cardiac murine tissue has never been explored …

Objective: One driving factor in the progression to posttraumatic osteoarthritis (PTOA) is the perpetu- ation of the inflammatory response to injury into chronic inflammation. Molecular imaging offers many opportunities to complement the sensitivity of …

Effects of hypertrophic challenge on small-conductance, Ca2+-activated K+ (SK2) channel expression were explored in intact murine hearts, isolated ventricular myocytes and neonatal rat cardiomyocytes (NRCMs). An established experimental platform applied …

Here, acidic tumor microenvironment (TME)-responsive nano-Bi2 Se3 @MnCaP, as a near-infrared-II (NIR-II) biowindow-triggered free radical generator for hypoxia-irrelevant phototherapy, is elaborately developed by biomimetic mineralization of MnCaP onto 2, …

Protein tyrosine phosphatase receptor-f1 (PTPRZ1) is a transmembrane tyrosine phosphatase receptor highly expressed in em- bryonic stem cells. In the present work, gene expression analyses of Ptprz1?/? and Ptprz1þ / þ mice endothelial cells and hearts …

The histologically identifiable cellular struc- ture(s) involved in ultrasonic scattering is(are) yet to be uniquely identified. The study quantifies six possible cel- lular scattering parameters, namely, cell and nucleus radii and their respective cell …

Purpose: Accurate identification and assessment of sentinel lymph node (SLN) using noninvasive imag- ing methods can play a vital role in tumor staging, surgical planning, and prognostic evaluation. In this study, we assessed the efficacy of …