Background: In pregnancy, nitric oxide (NO) plays important roles in embryo development, maternal cardiovascular function, fetoplacental blood flow and fetal growth. Whilst the importance of NO synthase (NOS)-derived NO has been studied in pregnancy, …

Background: MicroRNAs are post transcriptional modulators of gene expression. We explored the diagnostic and prognostic value of circulating microRNAs in abdominal aortic aneurysm (AAA) disease, for which currently no established circulating biomarker is …

Abnormal cholesterol metabolism promotes the immunosuppressive microenvironment of pancreatic cancer and affects the long-term efficacy of chemotherapy drugs. Accurate diagnosis and targeted microenvironment-remodeling are challenging during the …

Background: Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are conducted in animal models. To date, …

Background: Near-infrared fluorescence (NIRF) imaging assists surgeons intraoperatively to achieve radical resection of malignant tissue with one centimeter depth and can be supplemented with photoacoustic imaging to increase depth-of-view. …

Rationale: Pretargeted radioimmunotherapy (PRIT), which combines systemic antibody-based targeting with ionizing radiation, is promising for treating liver metastases in patients with colorectal cancer (CRC). Previously, we established a three-step …

Focused ultrasound ablation surgery (FUAS) combined with bacterial synergistic therapy has significant potential in solid tumors, however, this combination therapy has been limited mainly due to its weak anti-tumor effects, single imaging modality, and …

Background: Extracellular vesicles (EVs) are crucial mediators in brain metastasis (BM), facilitating pre-metastatic niche formation and metastatic progression. However, tracking their distribution and interactions in vivo remains challenging. Objective: …

Volatile organic compounds (VOCs) are widespread indoor gaseous pollutants that are associated with vascular diseases. However, due to methodological limitations, the underlying mechanisms of VOC-induced aortic fibrosis remains unclear. To address this …

Introduction: Despite the rapid development of small diameter vascular graft (SDVG), the ability of synthetic grafts to facilitate tissue remodeling and regeneration remains an important challenge within regenerative medicine. Methods: Based on our …