Background: Glucocorticoid (GC) intolerance and systemic toxicity pose significant challenges in the treatment of primary nephrotic syndrome (PNS), underscoring the urgent need for targeted therapies that maximize efficacy while minimizing adverse …

Background: Ubiquitin-specific peptidase 24 (USP24), a deubiquitinating enzyme, regulates protein stability by removing ubiquitin. This study investigates the role of UPS24 in lipid metabolism, inflammation, and fibrosis. It also explores the effect of …

Photo-crosslinkable gelatin-based hydrogels hold great promise for tissue engineering and regenerative medicine. However, monitoring these hydrogels in vivo remains challenging and limits their further development and clinical translation. Here, we …

Death-associated protein kinase 1 (DAPK1) is a tumor suppressor gene involved in apoptosis, autophagy, and tumor progression. However, its role in hypertension (HTN) remains largely unexplored and lacks systematic evaluation. We administered …

Atrial fibrillation (AF) is a common arrhythmia that increases the risk of stroke and heart failure and is associated with high morbidity and mortality. However, its molecular pathogenesis remains incompletely understood. In this study, we generated a …

Purpose Ultrasound combined with Doppler techniques has been widely utilized to evaluate joint inflammation and internal structural changes in animal models of rheumatoid arthritis. However, previous assessments using these techniques were predominantly …

Free gas micro-/nano-bubbles (MNBs) in water have demonstrated significant potential in various industrial applications, including water treatment, enhanced transport processes, and disinfection. However, the feasibility of utilizing MNBs water as a …

Novel Humanized Aortic Valve Calcification Model …

The mechanisms of sex differences in cerebrovascular function are not well understood. In this study, we determined whether sex differences in middle cerebral artery (MCA) reactivity are accompanied with changes in cerebral or systemic arterial resistance …

The development of nanosystems with enhanced photothermal and photoacoustic properties is crucial for advancing theranostic applications in cancer therapy. This study explores polymeric nanoparticles (NPs) constituted by a biocompatible poly(ethylene …