The C57BL/6 mouse strain is one of the most commonly used in experimental research. It is known to differ from other strains in baseline cardiovascular phenotypes as well as in response to pressure overload induced by aortic constriction. Since the …

Sedating animals is sometimes necessary in experimental research. This paper presents and discusses the influence of four of the most common anesthetic agents on cardiovascular parameters in rats. We also studied the influence of body temperature. …

Doxorubicin (DOX) is a drug commonly used for the treatment of cancer. The development of resistance to DOX is common, and high cumulative doses cause potentially lethal cardiac side ef- fects. HO-3867 (3,5-bis(4-fluorobenzylidene)-1-[(2,2,5,5-tetra- …

Aortic aneurysm is dilation of the aorta primarily due to degradation of the aortic wall extracellular matrix (ECM). Tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), the proteases that degrade the ECM. Timp3 is the …

OBJECTIVE: Activation of inflammatory pathways plays a critical role in the development of abdominal aortic aneurysms (AAA). Notch1 signaling is a significant regulator of the inflammatory response; however, its role in AAA is unknown. METHODS AND …

OBJECTIVE: Abdominal aortic aneurysms (AAA) are an age-related vascular disease and an important cause of morbidity and mortality. In this study, we sought to determine whether the catalytic component of telomerase, telomerase reverse transcriptase …

In our previous study, we showed that treatment with an anti-interleukin (IL)-12/23p40 antibody inhibits acute cardiac allograft rejection via inhibiting production of interferon (IFN)-γ and IL-17a. However, the impact of this antagonistic anti-p40 …

In vivo 3D rendered high-resolution ultrasound image of an E14 embryo and its associated placenta (on left). … … E14 mouse embryo …

In vivo 3D rendered co-registered high-resolution ultrasound (greyscale) and photoacoustic (red) image of an E14 embryo and its associated placenta (on left). The photoacoustic signal was acquired at 750nm and represents signal from mostly deoxygenated …

In vivo 3D rendered co-registered high-resolution ultrasound (greyscale) and photoacoustic (red, white and blue) image of an E14 embryo and its associated placenta (on left). The photoacoustic signal represents a parametric map of oxygen saturation with …