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Empagliflozin Improves Diastolic Function in a Nondiabetic Rodent Model of Heart Failure With Preserved Ejection Fraction
Recent studies send an unambiguous signal that the class of agents known as sodium-glucose–linked co-transporter-2 inhibitors (SGLT2i) prevent heart failure hospitalization in patients with type 2 diabetes. However, the mechanisms remain unclear. Herein …
Publication
Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis by activating multiple NRF2 downstream genes
Background and aims: Oxidative stress-induced endothelial dysfunction is considered to exert a vital role in the development of atherosclerotic coronary heart disease (CHD). NRF2 is a key transcriptional factor against oxidative stress through activation …
Publication
Role of smooth muscle cell p53 in pulmonary arterial hypertension
by Takayuki Wakasugi, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Masaaki Nakao, Makoto Hoyano, Takeshi Kashimura, Kazufumi Nakamura, Hiroshi Ito, Takashi Nojiri, Tomoyoshi Soga, Tohru Minamino Pulmonary …
Publication
Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation
Non-apoptotic forms of cell death can trigger sterile inflammation through the release of danger-associated molecular patterns, which are recognized by innate immune receptors. However, despite years of investigation the mechanisms which initiate …
Publication
Fine particulate matter-induced cardiovascular injury is associated with NLRP3 inflammasome activation in Apo E-/- mice
Epidemiological evidences have indicated that fine particulate matter (PM 2.5 ) is associated with the increased risk of cardiovascular morbidity and mortality. Although several mechanisms linking PM 2.5 and inflammatory responses have been widely …
Publication
Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice
Exercise can improve morbidity and mortality in heart failure patients; how- ever, the underlying mechanisms remain to be fully investigated. Thus, we investigated the effects of exercise on cardiac function and ventricular arrhyth- mias in myocardial …
Publication
Fluid dynamics and forces in the HH25 avian embryonic outflow tract
The embryonic outflow tract (OFT) eventually undergoes aorticopulmonary septation to form the aorta and pulmonary artery, and it is hypothesized that blood flow mechanical forces guide this process. We performed detailed studies of the geometry, wall …
Publication
Use of Antimetastatic SOD3-Mimetic Albumin as a Primer in Triple Negative Breast Cancer
Of the deaths attributed to cancer, 90% are due to metastasis. Treatments that prevent or cure metastasis remain elusive. Low expression of extracellular superoxide dismutase (EcSOD or SOD3) has been associated with poor outcomes and increased metastatic …
Publication
The pro-atherogenic response to disturbed blood flow is increased by a western diet, but not by old age
Atherogenic remodeling often occurs at arterial locations with disturbed blood flow (i.e., low or oscillatory) and both aging and western diet (WD) increase the likelihood for pro-atherogenic remodeling. However, it is unknown if old age and/or a WD …
Publication
Comparative determination of placental perfusion by magnetic resonance imaging and contrast-enhanced ultrasound in a murine model of intrauterine growth restriction
Introduction: Exploration of placental perfusion is essential in screening for dysfunctions impairing fetal growth. The objective of this study was to assess the potential value of contrast-enhanced ultrasonography (CEUS) and magnetic resonance imaging …