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Inorganic Arsenic Exposure Induces Sex Disparate Effects and Exacerbates Ischemia-Reperfusion Injury in the Female Heart
Arsenic is a common contaminant in drinking water throughout the world, and recent studies support a link between inorganic arsenic (iAS) exposure and ischemic heart disease in men and women. Female hearts exhibit an estrogen-dependent reduction in …
Publication
A near-infrared turn-on probe for in vivo chemoselective photoacoustic detection of fluoride ion
The detection of fluoride ion (F − ) in living subjects is of value for healthcare and environmental fields. Here, a near-infrared (NIR) turn-on photoacoustic (PA) probe composed of naphthalimide unit, namely LET-1, was developed for chemoselective …
Publication
Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease
Leigh syndrome is a mitochondrial disease characterized by neurological disorders, metabolic abnormality and premature death. There is no cure for Leigh syndrome; therefore, new therapeutic targets are urgently needed. In Ndufs4-KO mice, a mouse model of …
Publication
Acute and chronic remote ischemic conditioning attenuate septic cardiomyopathy, improve cardiac output, protect systemic organs, and improve mortality in a lipopolysaccharide-induced sepsis model
Remote ischemic conditioning (RIC) is acutely cardioprotective in ischemia–reperfusion injury. We aimed to evaluate the effect of RIC on septic cardiomyopathy and associated multi-organ failure in a lipopolysaccharide (LPS)-induced sepsis mouse model. …
Publication
Mechanical Deformation of Human Optic Nerve Head and Peripapillary Tissue in Response to Acute IOP Elevation
PURPOSE. To measure the deformation of the human optic nerve head (ONH) and peripapillary tissue (PPT) in response to acute intraocular pressure (IOP) elevation. METHODS. The ONH and PPT of 14 human donor globes were imaged with high-frequency …
Publication
JDP2 and ATF3 deficiencies dampen maladaptive cardiac remodeling and preserve cardiac function
c-Jun dimerization protein (JDP2) and Activating Transcription Factor 3 (ATF3) are closely related basic leucine zipper proteins. Transgenic mice with cardiac expression of either JDP2 or ATF3 showed maladaptive remodeling and cardiac dysfunction. …
Publication
Beneficial Effects of Mesenchymal Stem Cell Delivery via a Novel Cardiac Bioscaffold on Right Ventricles of Pulmonary Arterial Hypertensive Rats
Right ventricular failure (RVF) is a common cause of death in patients suffering from pulmonary arterial hypertension (PAH). The current treatment for PAH only moderately improves symptoms and RVF ultimately occurs. Therefore, it is necessary to develop …
Publication
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice
Clinical Relevance: Results from this study suggest a novel mode of intervening in the renin-angiotensin system to treat vascular diseases, namely, by activating Mas receptor (MasR) as the protective arm of the system. Our results demonstrate that when …
Publication
Myofilament Ca2+ sensitivity correlates with left ventricular contractility during the progression of pressure overload-induced left ventricular myocardial hypertrophy in rats
Aim: Here we aimed at investigating the relation between left ventricular (LV) contractility and myofilament function during the development and progression of pressure overload (PO)-induced LV myocardial hypertrophy (LVH). Methods: Abdominal aortic …
Publication
Variable outcomes of human heart attack recapitulated in genetically diverse mice
Variable outcomes of human heart attack recapitulated in genetically diverse mice …