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Mutations in DCHS1 cause mitral valve prolapse
Mitral valve prolapse (MVP) is a common cardiac valve disease that affects nearly 1 in 40 individuals1–3. It can manifest as mitral regurgitation and is the leading indication for mitral valve surgery4,5. Despite a clear heritable component, the genetic …
Publication
Morphological and Biomechanical Differences in the Elastase and AngII apoE −/− Rodent Models of Abdominal Aortic Aneurysms
An abdominal aortic aneurysm (AAA) is a potentially fatal cardiovascular disease with multifactorial development and progression. Two preclinical models of the disease (elastase perfusion and angiotensin II infusion in apolipoprotein-E-deficient animals) …
Publication
Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications
Rupture of abdominal aortic aneurysm (AAA) is a lethal event. No oral medicine has been available to prevent or treat AAA. We have recently identified a novel mechanism of eNOS uncoupling by which AAA develops, in angiotensin II (Ang II) infused …
Publication
Effects of High Intensity Interval Training on Pregnant Rats, and the Placenta, Heart and Liver of Their Fetuses
OBJECTIVE: To investigate the effects of high intensity interval training (HIIT) on the maternal heart, fetuses and placentas of pregnant rats. METHODS: Female Sprague-Dawley rats were randomly assigned to HIIT or sedentary control groups. The HIIT group …
Publication
Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity.
Angiotensin-converting enzyme 2 (ACE2) knockout is associated with reduced fetal weight at late gestation; however, whether uteroplacental vascular and/or hemodynamic disturbances underlie this growth-restricted phenotype is unknown. Uterine artery …
Publication
Comparative Myocardial Deformation in 3 Myocardial Layers in Mice by Speckle Tracking Echocardiography
Background . Speckle tracking echocardiography (STE) using dedicated high-resolution ultrasound is a relatively new technique that is useful in assessing myocardial deformation in 3 myocardial layers in small animals. However, comparative studies of STE …
Publication
High and low frequency subharmonic imaging of angiogenesis in a murine breast cancer model
This project compared quantifiable measures of tumor vascularity obtained from contrast-enhanced high frequency (HF) and low frequency (LF) subharmonic ultrasound imaging (SHI) to 3 immunohistochemical markers of angiogenesis in a murine breast cancer …
Publication
Ultrasound Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 Expression for Endometrial Receptivity Evaluation
Purpose: Ultrasound (US) molecular imaging by examining the expression\nof vascular endothelial growth factor receptor 2 (VEGFR2) on uterus\nvascular endothelium was applied to evaluate the endometrial\nreceptivity.\nMethods: VEGFR2-targeted ultrasound …
Publication
Monitoring and staging abdominal aortic aneurysm disease with pulse wave imaging.
The abdominal aortic aneurysm (AAA) is a silent and often deadly vascular disease caused by the localized weakening of the arterial wall. Previous work has indicated that local changes in wall stiffness can be detected with pulse wave imaging (PWI), which …
Publication
Subharmonic, non-linear fundamental and ultraharmonic imaging of microbubble contrast at high frequencies.
There is increasing use of ultrasound contrast agent in high-frequency ultrasound imaging. However, conventional contrast detection methods perform poorly at high frequencies. We performed systematic in vitro comparisons of subharmonic, non-linear …