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Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia
Background. Optimal phosphate control is an unmet need in chronic kidney disease (CKD). High serumphosphate increases calcification burden and is associatedwithmortality and cardio- vascular disease inCKD.Nicotinamide (NA) alone or in combi- nation with …
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Goats have always been considered very useful animals. Goats success is related to its excellent adaptability to the diicult mountain conditions, extreme weather and low value feed acceptance, versatile habits and high production considering their size. …
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A mouse model of heart failure exhibiting pulmonary edema and pleural effusion: Useful for testing new drugs
Introduction: Mouse models of chronic heart failure (HF) have been widely used in HF research. However, the current HF models most often use the C57BL/6 mouse strain and do not show the clinically relevant characteristics of pulmonary congestion. In this …
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SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart
Hyperglycaemia associated with myocardial oxidative stress and fibrosis is the main cause of diabetic cardiomyopathy. Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor has recently been reported to improve glycaemic control in patients …
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Platelet-derived β2M regulates monocyte inflammatory responses
β-2 Microglobulin (β2M) is a molecular chaperone for the major histocompatibility class I (MHC I) complex, hemochromatosis factor protein (HFE), and the neonatal Fc receptor (FcRn), but β2M may also have less understood chaperone-independent functions. …
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Preserved cardiovascular homeostasis despite blunted acetylcholine‐induced dilation in mice with endothelial muscarinic M3 receptor deletion
Aim: Muscarinic acetylcholine receptors (AChMR1‐5) are fundamental for cellular responses upon release of the neurotransmitter acetylcholine (ACh) from parasym- pathetic nerve fibers. ACh is the prototypical agonist stimulating endothelium‐de- pendent …
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PKA/β2-AR-Gs/Gi signaling pathway is associated with anti-inflammatory and pro-apoptotic effects of Fuzi and Banxia combination on rats subjected to pressure overload
Ethnopharmacological relevance: Either Aconite Lateralis Radix Praeparata (Fuzi) or Pinelliae Rhizoma (Banxia) exerts anti-inflammatory activity and their combination has long been used in China for treating cardiovascular diseases. However, combination …
Publication
RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) results in neurological damage, acute cardiac damage and has a high mortality rate. Immunoresponse in the acute phase after SAH plays a key role in mediating vasospasm, edema, inflammation and neuronal damage. The S1P/S1PR …
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Recent strategies on targeted delivery of thrombolytics
Thrombus formed in blood vessel is a progressive process, which would lead to life-threatening thrombotic diseases such as ischemic stroke. Unlike other diseases, the recognition of thrombus is usually in the late stage where blood vessels are largely …
Publication
Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity
Abstract Adults who experienced undernutrition during criticalwindows of development are at increased risk for cardiovascular disease. The contribution of cardiac function to this increased disease risk is uncertain.We evaluated the effect of a short …