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A chemical approach for global protein knockdown from mice to non-human primates
Although conventional genetic modification approaches for protein knockdown work very successfully due to the increasing use of CRISPR/Cas9, effective techniques for achieving protein depletion in adult animals, especially in large animals such as …
Publication
Maternal obesity and gestational diabetes: Impact on arterial wall layer thickness and stiffness in early childhood - RADIEL study six-year follow-up
Background and aims: Gestational diabetes (GDM) and maternal obesity are linked to weight gain in childhood and an increased risk of cardiovascular disease later in life. We assessed the effects of GDM and maternal obesity on arterial function and …
Publication
Involvement of lncR-30245 in myocardial infarction-induced cardiac fibrosis through PPAR-γ-mediated CTGF signaling pathway
Background Long noncoding RNAs (lncRNAs) are emerging as important mediators of cardiac pathophysiology. The aim of the present study is to investigate the effects of an lncRNA lncR-30245 on cardiac fibrogenesis and the underlying mechanism. Methods …
Publication
In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm
Aortic aneurysm is the most life-threatening complication in Marfan syndrome (MFS) patients. Doxycycline, a nonselective matrix metalloproteinases inhibitor, was reported to improve the contractile function and elastic fiber structure and organization in …
Publication
Graded murine wire-induced aortic valve stenosis model mimics human functional and morphological disease phenotype
Aortic valve stenosis (AS) is the most common valve disease requiring therapeutic intervention. Even though the incidence of AS has been continuously rising and AS is associated with significant morbidity and mortality, to date, no medical treat- ments …
Publication
Combination of Ligusticum Chuanxiong and Radix Paeonia Promotes Angiogenesis in Ischemic Myocardium through Notch Signalling and Mobilization of Stem Cells
Objective . To study the cardioprotective mechanism by which the combination of Chuanxiong (CX) and Chishao (CS) promotes angiogenesis. Methods . Myocardial infarction (MI) mouse models were induced by ligation of the left anterior descending coronary …
Publication
FNDC5/Irisin inhibits pathological cardiac hypertrophy
Cardiac hypertrophy is a common pathophysiological process in various cardiovascular dis- eases, which still has no effective therapies. Irisin is a novel myokine mainly secreted by skeletal muscle and is believed to be involved in the regulation of …
Publication
YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo
Specialized adult somatic cells, such as cardiomyo- cytes (CMs), are highly differentiated with poor renewal capacity, an integral reason underlying or- gan failure in disease and aging. Among the least renewable cells in the human body, CMs renew …
Publication
(Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease
BACKGROUND: The (pro)renin receptor [(P)RR)] is involved in the activation of local renin-angiotensin system and subsequent development of cardiovascular disease. We investigated the therapeutic effect of a (P)RR blocker, handle-region peptide (HRP), on …
Publication
Down-regulation of MYCN protein by CX-5461 leads to neuroblastoma tumor growth suppression
Purpose: MYCN oncogene amplification is an independent predictor of poor prognosis in neuroblastoma. CX-5461 is a small molecular inhibitor that prevents initiation of ribosomal RNA (rRNA) synthesis by RNA Pol I, down-regulating MYCN/MYC proteins. We …