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Tanshinone IIA protects against heart failure post-myocardial infarction via AMPKs/mTOR-dependent autophagy pathway
Heart failure (HF) leads to an increase in morbidity and mortality globally. Tanshinone IIA is an important traditional Chinese medicine monomer and has been shown to have remarkable protective effect against HF. Autophagy is critically involved in the …
Publication
Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation
Minocycline is a tetracycline antibiotic and has been shown to play a protective role in cerebral and myocardial ischemia/ reperfusion (I/R). However, the underlying mechanism remains unclear. Herein, we investigated whether monocyte chemotactic …
Publication
Reduced Amount or Integrity of Arterial Elastic Fibers Alters Allometric Scaling Relationships for Aortic Diameter and Heart Weight, But Not Cardiac Function in Maturing Mice
Allometric scaling laws relate physiologic parameters to body weight. Genetically modified mice allow investigation of allomet- ric scaling laws when fundamental cardiovascular components are altered. Elastin haploinsufficient (Elnþ/?) mice have reduced …
Publication
A noninvasive MRI based approach to estimate the mechanical properties of human knee ligaments
Characterization of the main tibiofemoral ligaments is an essential step in developing patient-specific compu- tational models of the knee joint for personalized surgery pre-planning. Tensile tests are commonly performed in-vitro to characterize the …
Publication
MG53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling
Background The aortic valve of the heart experiences constant mechanical stress under physiological conditions. Maladaptive valve injury responses contribute to the development of valvular heart disease. Here, we test the hypothesis that MG 53 (mitsugumin …
Publication
Human Mesenchymal Stem Cell Therapy Reverses Su5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Mice
Aims: Pulmonary arterial hypertension (PAH) is a disease characterized by an increase in pulmonary vascular resistance and right ventricular (RV) failure. We aimed to determine the effects of human mesenchymal stem cell (hMSC) therapy in a SU5416/hypoxia …
Publication
Alamandine attenuates arterial remodelling induced by transverse aortic constriction in mice
Aims: The renin–angiotensin system (RAS) plays an important role in the pathophysiol- ogy of vascular diseases, especially as a mediator of inflammation and tissue remodelling. Alamandine (Ala1-angiotensin-(1-7)) is a new biologically active peptide …
Publication
The ‘ALSPAC in London’ dataset: adiposity, cardiometabolic risk profiles, and the emerging arterial phenotype in young adulthood
Rising rates of adiposity in the young pose one of the greatest threats to future population burden of cardiovascular disease. Understanding the contribution of genetic and early-life influences to adiposity profiles in young adulthood – when the first …
Publication
Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy
Cardiomyopathy is a leading cause of death for Duchenne muscular dystrophy. Here, we find that the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) can share common ligands but play distinct roles in dystrophic heart and skeletal muscle …
Publication
Dacomitinib, a new pan-EGFR inhibitor, is effective in attenuating pulmonary vascular remodeling and pulmonary hypertension
Accumulating evidence suggests that epidermal growth factor receptor (EGFR) plays a role in the progression of pulmonary arterial hypertension (PAH). Clinically-approved epidermal growth factor inhibitors such as gefi- tinib, erlotinib, and lapatinib have …