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The α11 integrin mediates fibroblast–extracellular matrix–cardiomyocyte interactions in health and disease
Excessive cardiac interstitial fibrosis impairs normal cardiac function. We have shown that the α11β1 (α11) integrin mediates fibrotic responses to glycated collagen in rat myocardium by a pathway involving transforming growth factor-β. Little is known of …
Publication
Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice
Hyperaldosteronism is associated with an increased prevalence of atrial fibrillation (AF).Mutations in KCNE3 have been associated with AF, and Kcne32/2 mice exhibit hyperaldosteronism. In this study, we used recently developed Kcne32/2 mice to study …
Publication
In vivo assessment of coronary flow and cardiac function after bolus adenosine injection in adenosine receptor knockout mice
Abstract Bolus injections of adenosine and the A2A adenosine receptor (AR) selective agonist (regadenoson) are used clinically as a substitute for a stress test in people who cannot exercise. Using isolated tissue preparations, our lab has shown that …
Publication
Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice
Aims: Cardiac angiogenesis is an important determinant of heart failure.We examined the hypothesis that protein tyrosine phosphatase (PTP)-1B, a negative regulator of vascular endothelial growth factor (VEGF) receptor-2 activation, is caus- ally involved …
Publication
CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability
The irreversible loss of cardiomyocytes due to oxidative stress is the main cause of heart dysfunction following ischemia/reperfu- sion (I/R) injury and ageing-induced cardiomyopathy. Here, we report that CUEDC2, a CUE domain-containing protein, plays a …
Publication
Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro
There is accumulating evidence during sepsis that cardiomyocyte (CM) homeostasis is compromised, resulting in cardiac dysfunc- tion. An important role for complement in these outcomes is now demonstrated. Addition of C5a to electrically paced CMs caused …
Publication
Contrast agents for molecular photoacoustic imaging
Photoacoustic imaging (PAI) is an emerging tool that bridges the traditional depth limits of ballistic optical imaging and the resolution limits of diffuse optical imaging. Using the acoustic waves generated in response to the absorption of pulsed laser …
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Vevo Tips and Tricks
Image Guided Injections Shripad shares: Tips and Tricks for Image Guided Injections For myocardial or Embryo injections, 5ul is a sufficient volume. One inch 30 gauge needles are always good. These needles are not too rigid and flexible to inject through …