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Oxidation of Methionine 77 in Calmodulin Alters Mouse Growth and Behavior
Methionine 77 in calmodulin can be stereospecifically oxidized to methionine sulfoxide by mammalian methionine sulfoxide reductase A. Whether this has in vivo significance is unknown. We therefore created a mutant mouse in which wild type calmodulin-1 was …
Publication
Chitosan/silk fibroin modified nanofibrous patches with mesenchymal stem cells prevent heart remodeling post-myocardial infarction in rats
Poor functional survival of the engrafted stem cells limits the therapeutic efficacy of stem-cell-based therapy for myocardial infarction (MI). Cardiac patch-based system for cardiac repair has emerged as a potential regenerative strategy for MI. This …
Publication
Combined application of Indocyanine green (ICG) and laser lead to targeted tumor cell destruction
Purpose: Precise excision of neuroblastoma is challenging, especiallywhen tumors adhere to vital structures. In- docyanine green (ICG), an FDA-approved dye with absorption peaking at 800 nm, can absorb the near IR laser energy and release heat in the dyed …
Publication
Touch and tactile neuropathic pain sensitivity are set by corticospinal projections
Current models of somatosensory perception emphasize transmission from primary sensory neurons to the spinal cord and on to the brain1–4. Mental influence on perception is largely assumed to occur locally within the brain. Here we investigate whether …
Publication
Is the combinational administration of doxorubicin and glutathione a reasonable proposal?
The combinational administration of antioxidants and chemotherapeutic agents during conventional cancer treatment is among one of the most controversial areas in oncology. Although the data on the combinational usage of doxorubicin (DOX) and glutathione …
Publication
Azilsartan attenuates cardiac damage caused by high salt intake through the downregulation of the cardiac (pro)renin receptor and its downstream signals in spontaneously hypertensive rats
We examined whether the stimulation of the angiotensin II AT1 receptor increases the expression of the cardiac (pro)renin receptor ((P)RR) and its downstream signals and whether the blockade of the angiotensin II AT1 receptor by azilsartan decreases the …
Publication
The Quantitative Anatomy of the Dorsal Scapholunate Interosseous Ligament
Background: The anatomy of the scapholunate interosseous ligament (SLIL) has been described qualitatively in great detail, with recognition of the dorsal component’s importance for carpal stability. The purpose of this study was to define the quantitative …
Publication
Increases in plasma corin levels following experimental myocardial infarction reflect the severity of ischemic injury
Following acute myocardial infarction, clinical studies show alterations in the blood levels of corin, a cardiac-selective activator of the natriuretic peptides pro-atrial natriuretic peptide (pro-ANP) and pro-B-type natriuretic peptide (pro-BNP). …
Publication
Dragon's Blood exerts cardio-protection against myocardial injury through PI3K-AKT-mTOR signaling pathway in acute myocardial infarction mice model
Ethnopharmacological relevance: Dragon's Blood (DB), the red resin of Dracaena cochinchinensis (Lour.) S. C., has been used in traditional Chinese medicine to treat acute myocardial infarction (AMI) for centuries. Evidence indicated that DB may exert …
Publication
MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction
Background . To cure ischemic diseases, angiogenesis needs to be improved by various strategies in ischemic area. Considering that microRNA-132 (miR-132) regulates endothelial cell behavior during angiogenesis and the safe and efficacious delivery of …