Photoacoustic imaging combines the high contrast of optical imaging with the spatial resolution and penetration depth of ultrasound. This technique holds tremendous potential for imaging in small animals and importantly, is clinically translatable. At …

Preclinical, noninvasive imaging of tissue engineering polymeric scaffold structure and/or the physiological processes such as blood oxygenation remains a challenge. In vitro or ex vivo, the widely used scaffold characterization modalities such as …

Metastases rather than primary tumors are responsible for killing most patients with cancer. Cancer cells often invade regional lymph nodes (LN) before colonizing other parts of the body. However, due to the low sensitivity and specificity of current …

Photoacoustic imaging has evolved into a clinically translatable platform with the potential to complement existing imaging techniques for the management of cancer, including detection, characterization, prognosis, and treatment monitoring. In …

In utero exposure of rat embryos to dimethadione (DMO), the N-demethylated teratogenic metabolite of the anticonvulsant trimethadione, induces a high incidence of cardiac heart defects including ventricular septal defects (VSDs). The same exposure regimen …

Recent development of ultra high-resolution ultrasound systems, with frequencies as high as 70 MHz and capabil- ity resolution as fine as 30 lm, could permit new diagnostic applications to small parts. A variety of superficial targets within the first 1 …

Myocardial infarction (MI) is the leading cause of death in Western countries. Epidemiological studies show acute MI to be more preva- lent in the morning and to be associated with a poorer outcome in terms of mortality and recovery. The mechanisms behind …

Treatment options for patients with hepatocellular carcinoma (HCC) are limited, in particular in advanced and drug resistant HCC. MicroRNAs (miRNA) are non-coding small RNAs that are emerging as novel drugs for the treatment of cancer. The aim of this …

Background—Cardiac tests for diagnosing myocarditis lack sensitivity or specificity. We hypothesized that contrast- enhanced ultrasound molecular imaging could detect myocardial inflammation and the recruitment of specific cellular subsets of the …

Impaired cardiac diastolic function occurs with aging in many species and may be difficult to measure noninvasively. In humans, left atrial (LA) volume is a robust measure of chronic diastolic function as the LA is exposed to increased left ventricular …