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Asymmetric pulsation of rat carotid artery bifurcation in three-dimension observed by ultrasound imaging
Abstract The arterial structure cyclically fluctuates in three-dimensions (3-D) caused by pulsatile blood flow. The evaluation of arterial wall motion and hemodynam- ics contributes to early diagnosis of carotid atherosclerosis. Ultrasound is one of the …
Publication
Smooth muscle FGF/TGFbeta cross talk regulates atherosclerosis progression
The conversion of vascular smooth muscle cells (SMCs) from contractile to proliferative phenotype is thought to play an important role in atherosclerosis. However, the contribution of this process to plaque growth has never been fully defined. In this …
Publication
Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores
To determine whether hepatic de- pletion of vitamin A (VA) stores has an effect on the postnatal heart, studies were carried out with mice lacking liver retinyl ester stores fed either a VA-sufficient (LRVAS) or VA-deficient (LRVAD) diet (to deplete …
Publication
Chronic plus binge ethanol feeding induces myocardial oxidative stress, mitochondrial and cardiovascular dysfunction and steatosis
Alco- holic cardiomyopathy in humans develops in response to chronic excessive alcohol consumption; however, good models of alcohol- induced cardiomyopathy in mice are lacking. Herein we describe mouse models of alcoholic cardiomyopathies induced by …
Publication
Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux
Polydatin (PD), a resveratrol (RES) glycoside, has a stronger antioxidative effect than RES. It is known that RES is an autophagic enhancer and exerts a cardioprotective effect against ischaemia/reperfusion (I/R) injury. However, the effect of PD …
Publication
Postnatal Loss of Kindlin-2 Leads to Progressive Heart FailureCLINICAL PERSPECTIVE
BACKGROUND The striated muscle costamere, a multiprotein complex at the boundary between the sarcomere and the sarcolemma, plays an integral role in maintaining striated muscle structure and function. Multiple costamere-associated proteins, such as …
Publication
Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology
Cardiopulmonary complications are the leading cause of mortality in sickle cell anemia (SCA). Elevated tricuspid regurgitant jet velocity, pulmonary hypertension, diastolic, and autonomic dysfunction have all been described, but a unifying pathophysiology …
Publication
Loss of Mouse P2Y 6 Nucleotide Receptor Is Associated with Physiological Macrocardia and Amplified Pathological Cardiac Hypertrophy
The study of the mechanisms leading to cardiac hypertro- phy is essential to better understand cardiac development and regeneration. Pathological conditions such as ischemia or pressure overload can induce a release of extracellular nucleotides within the …
Publication
Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation
Phosphodiesterase 5 (PDE5) inhibitors limit myocardial injury caused by stresses, including doxorubicin chemotherapy. cGMP binding to PKG I ? attenuates oxidant-induced disulfide formation. Because PDE5 inhibition elevates cGMP and pro- tects from …
Publication
Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36
Cardiovascular disease (CVD) is the leading cause of the death worldwide. An increasing number of studies have found that autophagy is involved in the progression or prevention of CVD. However, the precise mechanism of autophagy in CVD, especially the …