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A dual-mode imaging catheter for intravascular ultrasound application
Both the morphological anatomy and functional parameters such as flow speed of the artery provide valuable information for the evaluation of cardiovascular diseases. Direct measurement of the arterial wall can be achieved by intravascular …
Publication
Signature-oriented investigation of the efficacy of multicomponent drugs against heart failure
Increasing attention has been paid to the application of precision medicine in heart failure (HF), and biomarker-based personalized medical care has shown great progress in HF management. Additionally, multi- component drugs represented by traditional …
Publication
Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H 2 O 2 and Catalase for Enhanced Radio-Immunotherapy of Cancer
The recent years have witnessed the blooming of cancer immunotherapy, as well as their combinational use together with other existing cancer treatment techniques including radiotherapy. However, hypoxia is one of several causes of the immunosuppressive …
Publication
Increased placental T cell trafficking results in adverse neurobehavioral outcomes in offspring exposed to sub-chronic maternal inflammation
Interleukin-1 beta (IL-1β) is a cytokine mediator of perinatal brain injury. The effect of sub-chronic systemic IL-1β exposure in perinatal and offspring outcomes is unclear. The aim of this study was to examine the effects of maternal IL-1β exposure on …
Publication
Rapamycin prevents thoracic aortic aneurysm and dissection in mice
Objective: The purpose of this study was to investigate whether rapamycin inhibits the development of thoracic aortic aneurysm and dissection (TAAD) in mice. Methods: Three-week-old C57BL/6J male mice were fed a normal diet and randomized into a control …
Publication
Surgery for Obesity and Related Diseases: II. Experimental Validation of Longitudinal Speed of Sound Estimates in the Diagnosis of Hepatic Steatosis
This study validates a non-invasive, quantitative technique to diagnose steatosis within tissue. The proposed method is based on two fundamental concepts: (i) the speed of sound in a fatty liver is lower than that in a healthy liver and (ii) the quality …
Publication
Clinical translation of a novel photoacoustic imaging system for examining the temporal artery
The objective was to provide a clinical setup for photoacoustic imaging (PAI) of the temporal artery in humans and to describe the challenges encountered and methods of overcoming them. The temporal artery was examined in 7 patients with suspect giant …
Publication
CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias
Background-—The sodium channel, Nav1.5, encoded by SCN5A, undergoes developmentally regulated splicing from inclusion of exon 6A in the fetal heart to exon 6B in adults. These mutually exclusive exons differ in 7 amino acids altering the …
Publication
Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival
Angiocrine signals derived from endothelial cells are an important component of intercellular communication and have a key role in organ growth, regeneration and disease1–4. These signals have been identified and studied in multiple organs, including the …
Publication
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
No effective treatments currently exist for placenta-associated pregnancy complications, and developing strategies for the targeted delivery of drugs to the placenta while minimizing fetal and maternal side effects remains challenging. Targeted …