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Ablation of the stress protease OMA1 protects against heart failure in mice
Current therapies for heart failure vary depending on the root cause and stage of the disease. Acin-Perez et al . studied the molecular link between mitochondrial dysfunction and heart failure, focusing on OMA1, a protease involved in mitochondrial inner …
Publication
Ginsenoside Rb1 inhibits autophagy through regulation of Rho/ROCK and PI3K/mTOR pathways in a pressure-overload heart failure rat model
Objective This study was designed to explore the relationship between gin- senoside Rb1 (Grb1) and high-load heart failure (HF) in rats. Methods The parameters of cardiac systolic function (left ventricular posterior wall thickness (LVPWT), left …
Publication
CXCL8 hyper-signaling in the aortic abdominal aneurysm
There are indications for elevated CXCL8 levels in abdominal aortic aneurysm disease (AAA). CXCL8 is concurrently involved in neutrophil-mediated inflammation and angiogenesis, two prominent and distinctive characteristics of AAA. As such we considered an …
Publication
MiR-124 aggravates failing hearts by suppressing CD151-facilitated angiogenesis in heart
Heart failure (HF) is the final common pathway of various cardiovascular diseases. Although it is well documented that reduction of cardiac angiogenesis contributes to the progression from adaptive cardiac hypertrophy to HF, the molecular mechanisms …
Publication
Photoacoustic imaging of synovial tissue hypoxia in experimental post-traumatic osteoarthritis.
OBJECTIVES: This pilot study aimed to investigate the feasibility of non-invasively assessing synovial tissue hypoxia in vivo using photoacoustic (PA) imaging in a post-traumatic osteoarthritis model and explore its correlation with OA severity. METHODS: …
Publication
Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers
RATIONALE: Diaphragm weakness in critically ill patients prolongs ventilator dependency and duration of hospital stay, and increases mortality and health care costs. The mechanisms underlying diaphragm weakness include cross-sectional fiber atrophy and …
Publication
Specific circulating microRNAs display dose-dependent responses to variable intensity and duration of endurance exercise
Circulating microRNAs (c-miRNAs) - plasma-based noncoding RNAs that control post-transcriptional gene expression - mediate processes that underlie phenotypic plasticity to exercise. The relationship and biologic relevance between c-miRNA expression and …
Publication
TLR4 activation promotes the progression of experimental autoimmune myocarditis to dilated cardiomyopathy by inducing mitochondrial dynamics imbalance
Mitochondrial dynamics imbalance associates with several cardiovascular diseases. However, the role of mitochondrial dynamics in TLR4 activation mediated dilated cardiomyopathy (DCM) progress remains unknown. A model of experimental autoimmune myocarditis …
Publication
Dual-modal photoacoustic and magnetic resonance tracking of tendon stem cells with PLGA/iron oxide microparticles in vitro
Reliable cell tracking is essential to understand the fate of stem cells following implantation, and thus promote the clinical application of stem cell therapy. Dual or multiple modal imag- ing modalities mediated by different types of multifunctional …
Publication
Skeletal, cardiac, and respiratory muscle function and histopathology in the P448Lneo− mouse model of FKRP-deficient muscular dystrophy
Background: Fukutin-related protein (FKRP) mutations are the most common cause of dystroglycanopathies known to cause both limb girdle and congenital muscular dystrophy. The P448Lneo− mouse model has a knock-in mutation in the FKRP gene and develops …