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A versatile method for the preparation of poly-acrylamide derivative functionalized thermo-responsive gold nanoparticles
Abstract: Herein we report the synthesis of a resilient nanosystem based on silica-coated magnetic MnFe2O3 nanoparticles conjugated to fluorescein and PEGylated gold nanorods embedded in polymeric micelles (MnFe2O4@SiO2@GNRs@PMs), for …
Publication
Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity
Multi-layered single-walled carbon nanotubes, termed SWNT@BSA@Au-S-PEG-FA@DOX, which integrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process. Oxidized and cut single-walled carbon …
Publication
HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction
Alternative splicing of RNA is an underexplored area of transcriptional response. We expect that early changes in alternatively spliced genes may be important for responses to cardiac injury. Hypoxia inducible factor 1 (HIF1) is a key transcription factor …
Publication
Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension
RATIONALE: Angioproliferative vasculopathy is a hallmark of pulmonary arterial hypertension (PAH). However, little is known how endothelial cell (EC) and smooth muscle cell (SMC) crosstalk regulates the angioproliferative vascular remodeling. OBJECTIVES: …
Publication
Suppression of lncR-30245 alleviates myocardial infarction induced cardiac fibrosis via the PPAR-γ/CTGF pathway
Background Long noncoding RNAs (lncRNAs) are emerging as important mediators of cardiac pathophysiology. The aim of the present study is to investigate the effects of an lncRNA lncR-30245 on cardiac fibrogenesis and the underlying mechanism. Methods …
Publication
GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress
The clinical use of doxorubicin for cancer therapy is limited by its cardiotoxicity, which involves cardiomyocyte apoptosis and oxidative stress. Previously, we showed that general control nonderepressible 2 (GCN2), an eu- karyotic initiation factor 2α …
Publication
Glucose-regulated protein 78 is essential for cardiac myocyte survival
Secretory and transmembrane proteins rely on proper function of the secretory pathway for folding, posttranslational modification, assembly, and secretion. Accumulation of misfolded proteins in the endoplasmic reticulum (ER) stimulates the unfolded …
Publication
Spheroids of cardiomyocytes derived from human induced-pluripotent stem cells improve recovery from myocardial injury in mice
The microenvironment of native heart tissue may be better replicated when cardiomyocytes are cultured in three-dimensional clusters (i.e., spheroids) than in monolayers or as individual cells. Thus, we differentiated human, cardiac-lineage, …
Publication
Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice
We have previously demonstrated that adult transgenic C57BL/6J mice with CM-restricted overexpression of the dominant negative Wv mutant protein (dn-c-kit-Tg) respond to pressure overload with robust cardiomyocyte (CM) cell cycle entry. Here, we tested if …
Publication
Klf4 has an unexpected protective role in perivascular cells within the microvasculature
Recent smooth muscle cell (SMC) lineage tracing studies have revealed SMCs undergo remarkable changes in phenotype during development of atherosclerosis. Of major interest, we demonstrated that KLF4 in SMC is detrimental for overall lesion pathogenesis in …