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Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability
Locomotion is an essential animal behavior used for translocation. The spinal cord acts as key executing center, but how it coordinates many body parts located across distance remains poorly under- stood. Here we employed mouse genetic and viral …
Publication
Bcl-2–associated athanogene 3 protects the heart from ischemia/reperfusion injury
Introduction Bcl-2–associated athanogene 3 (BAG3) is a 575–amino acid protein that is highly conserved in nature (1). First identified by its ability to bind Bcl-2, BAG3 is expressed most abundantly in the heart and skeletal muscle and in many cancers. …
Publication
Validation of ultrasonography for non-invasive assessment of diaphragm function in muscular dystrophy
Abstract Duchennemuscular dystrophy (DMD) is a severe, degenerativemuscle disease caused by dystrophin mutations. The mdx mouse is a widely used animal model of DMD. The mdx diaphragmmuscle most closely recapitulates key features ofDMDmuscles, including …
Publication
Myocardial Infarction Promoted the Contrast-Induced Nephropathy by Renal Injury
Abstract Background: The morbidity of myocardial infarction is keeping raise in this decade. Because of high safety and operability , percutaneous coronary intervention(PCI) has been used to conquer this disease for more than 20 years.An important …
Publication
A Selective TGFβ Ligand Trap Attenuates Pulmonary Hypertension.
RATIONALE Transforming Growth Factor-β (TGFβ) ligands signal via type I and type II serine-threonine kinase receptors to regulate broad transcriptional programs. Excessive TGFβ-mediated signaling is implicated in the pathogenesis of pulmonary arterial …
Publication
Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. This study was aimed at evaluating the efficacy of AR-42 (formerly OSU-HDAC42), a novel histone deacetylase (HDAC) inhibitor currently in …
Publication
Murine Double Minute-2 Inhibition Attenuates Cardiac Dysfunction and Fibrosis by Modulating NF-κB Pathway After Experimental Myocardial Infarction
Abstract—Inflammation has been implicated in myocardial infarction (MI). MDM2 associates with n- uclear factor-κB(NF-κB)-mediated inflammation. However, the role ofMDM2 inMI remains unclear. This study aimed to evaluate the impacts ofMDM2 inhibition on …
Publication
Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism
Qishen granules (QSG), a traditional Chinese medicine, have been prescribed widely in the treatment of coronary heart diseases. Previous studies demonstrated that QSG had anti-inflammatory and cardio-protective effects in mice with acute myocardial …
Publication
Inwardly-rectifying K + channels are major contributors to flow-induced vasodilation in resistance arteries
Aims: Inwardly rectifying K+ (Kir) channels are known to be sensitive to flow, but their role in flow-induced endothelial responses is not known. The goal of this study is to establish the role of Kir channels in flow-induced vasodilation and to provide …
Publication
Aldehyde dehydrogenase 2 deficiency negates chronic low-to-moderate alcohol consumption-induced cardioprotecion possibly via ROS-dependent apoptosis and RIP1/RIP3/MLKL-mediated necroptosis
Previous studies evidenced the beneficial effects of low-to-moderate alcohol consumption on cardiovascular sys- temby activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2), a key enzyme metabolizing acetalde- hyde to innocuous acetic acid, in …