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Publication
A practical approach to remote ischemic preconditioning and ischemic preconditioning against myocardial ischemia/reperfusion injury
Although urgently needed in clinical practice, a cardioprotective therapeutic approach against myocardial ischemia/ reperfusion injury remains to be established. Remote ischemic preconditioning (rIPC) and ischemic preconditioning (IPC) represent promising …
Publication
The role of transient receptor potential vanilloid 2 channel in cardiac aging
Background The aging heart is characterized by cellular and molecular changes leading to a decline in physiologic function and cardiac remodeling, specifically the development of myocyte hypertrophy and fibrosis. Transient receptor potential vanilloid 2 …
Publication
Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction
Rationale: Phosphodiesterase 2 (PDE2) is a dual substrate esterase, which has the unique property to be stimulated by cGMP, but primarily hydrolyses cAMP. Myocardial PDE2 is upregulated in human heart failure (HF), but its role in the heart is unknown. …
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Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nu- clear lamina alterations, severe cardiovascular pathology, and pre- mature death. Prelamin A alterations also occur in …
Publication
VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection
Congestive heart failure is one of the leading causes of disability in long-term survivors of cancer. The anthracycline antibiotic doxo- rubicin (DOX) is used to treat a variety of cancers, but its utility is limited by its cumulative cardiotoxicity. As …
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Congenital valvular defects associated with deleterious mutations in the PLD1 gene
BACKGROUND The underlying molecular aetiology of congenital heart defects is largely unknown. The aim of this study was to explore the genetic basis of non-syndromic severe congenital valve malformations in two unrelated families. METHODS Whole-exome …
Publication
Comparison of Arterial Input Function Models for Small-Animal Ultrasound Perfusion Imaging
Background, Motivation and Objective Bolus & burst (B&B) is a method for quantitative ultrasound perfusion analysis combining bolus tracking and burst replenishment. Estimation of perfusion parameters is based on blind deconvolution where the measured …
Publication
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
The Frank–Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and …
Publication
Influence of shear stress magnitude and direction on atherosclerotic plaque composition
The precise flow characteristics that promote different atherosclerotic plaque types remain unclear. We previously developed a blood flow-modifying cuff for ApoE−/− mice that induces the development of advanced plaques with vulnerable and stable features …
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Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomerization
Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomeriza- tion. Am J Physiol Heart Circ Physiol 311: H1051–H1062, 2016. First published September 2, 2016; …