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High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography
High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic …
Publication
Magnetic Resonance Imaging of Cardiac Strain Pattern Following Transplantation of Human Tissue Engineered Heart MusclesCLINICAL PERSPECTIVE
As a major amino acid, glycine has multiple functions in metabolism, growth, immunity, cytoprotection, and survival. The aim of this study was to determine the effects of glycine on pathologic cardiac hyper- trophy and the mechanism underlying it. …
Publication
Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome
Marfan syndrome (MFS) is an autosomal-dominant disorder of connective tissue caused by mutations in the fibrillin-1 (FBN1) gene. Mortality is often due to aortic dissection and rupture. Weinvestigated the structural and functional properties of the heart …
Publication
Aliskiren protects against myocardial ischemia-reperfusion injury via an endothelial nitric oxide synthase dependent manner
Aliskiren, a direct renin inhibitor, was shown potent ability to attenuate hypertension. Our previous research has found that aliskiren protected against myocardial ischemia-reperfusion (I/R) injury and enhanced phosphorylation of endothelial nitric oxide …
Publication
ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerances
Aims Obesity and type 2 diabetes (T2D) trigger a harmful stress-induced cardiac remodeling process known as cardiomyopathy. These diseases represent a serious and widespread health problem in the Western world; however, the underlying molecular basis is …
Publication
Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library– Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene
Disturbed blood flow (d-flow) induces atherosclerosis by altering the expression of mechanosensitive genes in the arterial endothelium. Previously, we identified > 580 mechanosensitive genes in the mouse arterial endothelium, but their role in endothelial …
Publication
Comparison between sparse and concentrated scattering models for characterization of cell-pellet biophantoms and excised mouse tumors
Three scattering models were examined for characterizing in vitro biophantoms and ex vivo colon adenocarcinoma (HT29) mouse tumors in the 10-42 MHz and the 15-42 MHz frequency bandwidth, respectively. The Spherical Gaussian Model (SGM) and the …
Publication
Wave intensity analysis in mice: age-related changes in WIA peaks and correlation with cardiac indexes
Mouse models are increasingly employed in the comprehension of cardiovascular disease. Wave Intensity Analysis (WIA) can provide information about the interaction between the vascular and the cardiac system. We investigate age-associated changes in …
Publication
Establishment of a new acute-on-chronic liver failure model
To establish an animal model of acute-on-chronic liver failure (ACLF) that would replicate the pathological process of ACLF in humans, rats were administered porcine serum (PS) for 11 weeks. Liver fibrosis was determined by pathological and biochemical …
Publication
Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart
Sympathetic stimulation modulates L-type calcium channel (LTCC) gating to contribute to increased systolic heart function. Rad is a monomeric G-protein that interacts with LTCC. Genetic deletion of Rad (Rad−/−) renders LTCC in a sympathomimetic state. The …