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Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we show that pluripotent stem cell aggregates pre-differentiated …
Publication
Toll-like receptor 4 mutation suppresses hyperhomocysteinemia-induced hypertension
Hyperhomocysteinemia (HHcy) has been observed to promote hypertension, but the mechanisms are unclear. Toll-like receptor 4 (TLR-4) is a cellular membrane protein that is ubiquitously expressed in all cell types of the vasculature. TLR-4 activation has …
Publication
Increased complements and high-sensitivity C-reactive protein predict heart failure in acute myocardial infarction
The aim of the present study was to investigate whether the serum levels of complements and high-sensitivity C-reactive protein (hs-CRP) in patients with acute myocardial infarction (AMI) are associated with the severity of myocardial injury. Consecutive …
Publication
Resveratrol Reverses Functional Chagas Heart Disease in Mice
Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of parasite burden. During disease, the heart undergoes oxidative stress, a potential …
Publication
Assessment of murine colorectal cancer by micro-ultrasound using three dimensional reconstruction and non-linear contrast imaging
The relatively low success rates of current colorectal cancer (CRC) therapies have led investigators to search for more specific treatments. Vertebrate models of colorectal cancer are essential tools for the verification of new therapeutic avenues such as …
Publication
Postinjury biomechanics of Achilles tendon vary by sex and hormone status
Achilles tendon ruptures are common injuries. Sex differences are present in mechanical properties of uninjured Achilles tendon, but it remains unknown if these differences extend to tendon healing. We hypothesized that ovariectomized females (OVX) and …
Publication
Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice
AIMS Bone morphogenetic protein (BMP) signalling plays a key role in regulating the development of the atrioventricular (AV) septum and valves; however, the molecules that mediate the complex activities of BMP signalling are not fully understood. The …
Publication
Obligatory role for GPER in cardiovascular aging and disease
Pharmacological activation of the heptahelical G protein-coupled estrogen receptor (GPER) by selective ligands counteracts multiple aspects of cardiovascular disease. We thus expected that genetic deletion or pharmacological inhibition of GPER would …
Publication
Defective branched chain amino acids catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction
Cardiac metabolic remodeling is a central event during heart failure (HF) development following myocardial infarction (MI). It is well-known that myocardial glucose and fatty acids dysmetabolism contributes to post-MI cardiac dysfunction and remodeling. …
Publication
Mitochondrial tRNA mutation with high-salt stimulation on cardiac damage: underlying mechanism associated with change of Bax and VDAC
Mitochondrial transfer RNA (tRNA) mutation with high-salt stimulation can cause high blood pressure. However, the underlying mechanisms remain unclear. In the present study, we examined the potential molecular mechanisms of cardiac damage caused by …