Search
Publication
Knockdown of Salusin- β Improves Cardiovascular Function in Myocardial Infarction-Induced Chronic Heart Failure Rats
Salusin-β is a biologically active peptide with 20 amino acids that exerts several cardiovascular activity-regulating effects, such as regulating vascular endothelial function and the proliferation of vascular smooth muscle cells. However, the regulatory …
Publication
Early treatment with combination of SS31 and entresto effectively preserved the heart function in doxorubicin-induced dilated cardiomyopathic rat
Background: This study tested the hypothesis that early administration of SS31 and entresto (En) was superior to either one alone on preserving the heart function in setting of dilated cardiomyopathy (DCM) induced by doxorubicin (Dox) [accumulated dosage …
Publication
Hirsutella sinensis fungus improves cardiac function in mouse model of heart failure
Cordyceps sinensis, including Hirsutella sinensis, is a highly valuable traditional Chinese medicine and is used to treat patients with pulmonary heart disease in clinical practice. However, the underlying mechanisms of its effects remain unclear. In this …
Publication
Effects of Angiotensin Converting Enzyme 2 and Angiotensin Converting Enzyme Genes on Cardiac Remodeling in Rats with Heart Failure
To investigate the effects of angiotensin converting enzyme 2 and angiotensin converting enzyme genes on the cardiac remodeling process in heart failure rats. 38 rats were randomly divided into sham-operated group (S group), heart failure group (H group) …
Publication
3D-Printed Scaffolds Promote Angiogenesis by Recruiting Antigen-Specific T Cells
The immune response after implantation is a primary determinant of the tissue-repair effects of three- dimensional (3D)-printed scaffolds. Thus, scaffolds that can subtly regulate immune responses may dis- play extraordinary functions. Inspired by the …
Publication
Early Detection and Reversal of Cell Apoptosis Induced by Focused Ultrasound-Mediated Blood-Brain Barrier Opening
Focused ultrasound (FUS) combined with microbubbles (MBs) has recently emerged as a potential approach to open the blood-brain barrier (BBB) for delivering drugs into the brain. However, appropriate approaches are still lacking to monitor the sublethal …
Publication
A neonatal leporine model of age-dependent natural heart regeneration after myocardial infarction
Objectives: Neonatal rodents and piglets naturally regenerate the injured heart after myocardial infarction. We hypothesized that neonatal rabbits also exhibit natural heart regeneration after myocardial infarction. Methods: New Zealand white rabbit kits …
Publication
Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity
Obesity, type 2 diabetes, and heart disease are linked to an unhealthy diet. Sarco(endo)plasmic reticulum calcium (Ca2+) ATPase 2a (SERCA2a) controls cardiac function by transporting Ca2+ in cardiomyocytes. SERCA2a is altered by diet and acetylation, …
Publication
Pneumonia initiates a tauopathy
Pneumonia causes short- and long-term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia-elicited cytotoxic amyloid and tau variants: (1) …
Publication
Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction
In recent decades, treatments for myocardial infarction (MI), such as stem and progenitor cell therapy, have attracted considerable scientific and clinical attention but failed to improve patient outcomes. These efforts indicate that more rigorous …