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PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis
Mutations in the PTRF/Cavin-1 gene cause congenital generalized lipodystrophy type 4 (CGL4) associated with myopathy. Additionally, long-QT syndrome and fatal cardiac arrhythmia are observed in patients with CGL4 who have homozygous PTRF/Cavin-1 …
Publication
TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice
First line treatment for recurrent and metastatic prostate cancer is androgen deprivation therapy (ADT).UseofADThasbeenincreasing infrequencyandduration, such that side effects increasingly impact patient quality of life. One of the most significant side …
Publication
Neonatal Arterial Morphology Is Related to Body Size in Abnormal Human Fetal GrowthCLINICAL PERSPECTIVE
BACKGROUND Restriction in fetal growth is associated with cardiovascular disease in adulthood. It is unclear whether abnormal intrauterine growth influences arterial morphology during the fetal or neonatal stage. The objective was to study the regional …
Publication
Biomimicking Platelet-Monocyte Interactions as a Novel Targeting Strategy for Heart Healing
In patients who survive myocardial infarction, many go on to develop congestive heart failure (CHF). Despite ongoing efforts to develop new approaches for postinfarction therapy, there are still no effective therapeutic options available to CHF patients. …
Publication
Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice
MicroRNAs play a crucial role in the regulation of pathological cardiac remodeling and heart failure. Previously, we found that overexpression of miR-221 induces heart failure in mice. The miR-222 and miR-221 share the same gene cluster, however, the role …
Publication
Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth through Disturbed Downstream TGF-β Signaling
Aneurysm-osteoarthritis syndrome characterized by unpredictable aortic aneurysm formation, is caused by SMAD3 mutations. Smad3 is part of the Smad2/3/4 transcription factor, essential for TGF-β-activated transcription. Although TGF-β-related gene …
Publication
Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture
Previous studies have demonstrated a significantly lower level of Hand1 in ischemic cardiomyopathy than in normal heart tissue. The role of decreased Hand1 in myocardial infarction remains unclear. This study was designed to investigate the effects of …
Publication
Myocardial Ischemia/Reperfusion impairs neurogenesis and hippocampal-dependent learning and memory
The incidence of cognitive impairment in cardiovascular disease (CVD) patients has increased, adversely impacting quality of life and imposing a significant economic burden. Brain imaging of CVD patients has detected changes in the hippocampus, a brain …
Publication
Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies
Tumor hypoxia is known to be one of critical reasons that limit the efficacy of cancer therapies, particularly photodynamic therapy (PDT) and radiotherapy (RT) in which oxygen is needed in the process of cancer cell destruction. Herein, taking advantages …
Publication
In vivo photoacoustic flowmetry at depths of the diffusive regime based on saline injection
We propose a saline injection-based method to quantify blood flow velocity in vivo with acoustic-resolution photoacoustic tomography. By monitoring the saline–blood interface propagating in the blood vessel, the flow velocity can be resolved. We first …