Search
Publication
Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux
Polydatin (PD), a resveratrol (RES) glycoside, has a stronger antioxidative effect than RES. It is known that RES is an autophagic enhancer and exerts a cardioprotective effect against ischaemia/reperfusion (I/R) injury. However, the effect of PD …
Publication
Postnatal Loss of Kindlin-2 Leads to Progressive Heart FailureCLINICAL PERSPECTIVE
BACKGROUND The striated muscle costamere, a multiprotein complex at the boundary between the sarcomere and the sarcolemma, plays an integral role in maintaining striated muscle structure and function. Multiple costamere-associated proteins, such as …
Publication
Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology
Cardiopulmonary complications are the leading cause of mortality in sickle cell anemia (SCA). Elevated tricuspid regurgitant jet velocity, pulmonary hypertension, diastolic, and autonomic dysfunction have all been described, but a unifying pathophysiology …
Publication
Loss of Mouse P2Y 6 Nucleotide Receptor Is Associated with Physiological Macrocardia and Amplified Pathological Cardiac Hypertrophy
The study of the mechanisms leading to cardiac hypertro- phy is essential to better understand cardiac development and regeneration. Pathological conditions such as ischemia or pressure overload can induce a release of extracellular nucleotides within the …
Publication
Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation
Phosphodiesterase 5 (PDE5) inhibitors limit myocardial injury caused by stresses, including doxorubicin chemotherapy. cGMP binding to PKG I ? attenuates oxidant-induced disulfide formation. Because PDE5 inhibition elevates cGMP and pro- tects from …
Publication
Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36
Cardiovascular disease (CVD) is the leading cause of the death worldwide. An increasing number of studies have found that autophagy is involved in the progression or prevention of CVD. However, the precise mechanism of autophagy in CVD, especially the …
Publication
The α11 integrin mediates fibroblast–extracellular matrix–cardiomyocyte interactions in health and disease
Excessive cardiac interstitial fibrosis impairs normal cardiac function. We have shown that the α11β1 (α11) integrin mediates fibrotic responses to glycated collagen in rat myocardium by a pathway involving transforming growth factor-β. Little is known of …
Publication
Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice
Hyperaldosteronism is associated with an increased prevalence of atrial fibrillation (AF).Mutations in KCNE3 have been associated with AF, and Kcne32/2 mice exhibit hyperaldosteronism. In this study, we used recently developed Kcne32/2 mice to study …
Publication
In vivo assessment of coronary flow and cardiac function after bolus adenosine injection in adenosine receptor knockout mice
Abstract Bolus injections of adenosine and the A2A adenosine receptor (AR) selective agonist (regadenoson) are used clinically as a substitute for a stress test in people who cannot exercise. Using isolated tissue preparations, our lab has shown that …
Publication
Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice
Aims: Cardiac angiogenesis is an important determinant of heart failure.We examined the hypothesis that protein tyrosine phosphatase (PTP)-1B, a negative regulator of vascular endothelial growth factor (VEGF) receptor-2 activation, is caus- ally involved …