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Accelerated Blood Clearance Phenomenon Reduces the Passive Targeting of PEGylated Nanoparticles in Peripheral Arterial Disease
Peripheral arterial disease (PAD) is a leading global health concern. Due to limited imaging and therapeutic options, PAD and other ischemia-related diseases may benefit from the use of long circulating nanoparticles as imaging probes and/or drug delivery …
Publication
Narrow Absorption NIR Wavelength Organic Nanoparticles Enable Multiplexed Photoacoustic Imaging
Photoacoustic (PA) imaging is an emerging hybrid optical- ultrasound based imaging technique that can be used to visualize optical absorbers in deep tissue. Free organic dyes can be used as PA contrast agents to concurrently provide additional …
Publication
Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging
Gold nanoparticles (AuNP) have been proposed for many applications in medicine. Although large AuNP (> 5.5??nm) are desirable for their longer blood circulation and accumulation in diseased tissues, small AuNP …
Publication
Multimodal near-infrared-emitting PluS Silica nanoparticles with fluorescent , photoacoustic , and photothermal capabilities
Purpose: The aim of the present study was to develop nanoprobes with theranostic features, including – at the same time – photoacoustic, near-infrared (NIR) optical imaging, and pho- tothermal properties, in a versatile and stable core–shell …
Publication
Lung ultrasound is a reliable method for evaluating extravascular lung water volume in rodents
BACKGROUND: Lung ultrasound (LUS) can diagnose extravacular lung water (EVLW) through the visualization of B lines in both humans and large animals. However, there are no published data on the use of ultrasound to detect EVLW in rats, the gold standard to …
Publication
Postnatal Cardiovascular Consequences in the Offspring of Pregnant Rats Exposed to Smoking and Smoking Cessation Pharmacotherapies
Approximately 20% of pregnant women smoke despite intentions to quit. Smoking cessation drugs, such as nicotine replacement therapy (NRT) and bupropion, are recommended treatments. Adverse cardiovascular outcomes in offspring have raised concerns about …
Publication
cAMP-PKA-CaMKII signaling pathway is involved in aggravated cardiotoxicity during Fuzi and Beimu Combination Treatment of Experimental Pulmonary Hypertension
Aconiti Lateralis Radix Praeparata (Fuzi) and Fritillariae Thunbergii bulbus (Beimu) have been widely used clinically to treat cardiopulmonary related diseases in China. However, according to the classic rules of traditional Chinese medicine, Fuzi and …
Publication
Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase
Increased levels of a cleaved form of prolactin (molecular weight 16 kDa) have been associated with preeclampsia. To study the effects of prolactin on blood pressure (BP),we generated male mice with a single-copy transgene (Tg; inserted into the …
Publication
Impact of cardiac-specific expression of CD39 on myocardial infarct size in mice
ABSTRACT Aims: Prior work suggests that ischemic preconditioning increases the level of CD39 in the heart and contributes to cardiac protection. Therefore, we examined if targeted cardiac expression of CD39 protects against myocardial injury. Main …
Publication
Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats
Sympathetic activity is enhanced in patients with essential or secondary hypertension, as well as in various hypertensive animal models. Therapeutic targeting of sympathetic activation is considered an effective antihypertensive strategy. We hypothesized …