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In Utero dimethadione exposure causes postnatal disruption in cardiac structure and function in the rat
In utero exposure of rat embryos to dimethadione (DMO), the N-demethylated teratogenic metabolite of the anticonvulsant trimethadione, induces a high incidence of cardiac heart defects including ventricular septal defects (VSDs). The same exposure regimen …
Publication
Ultra high-frequency ultrasound: New capabilities for nail anatomy exploration
Recent development of ultra high-resolution ultrasound systems, with frequencies as high as 70 MHz and capabil- ity resolution as fine as 30 lm, could permit new diagnostic applications to small parts. A variety of superficial targets within the first 1 …
Publication
The time‐of‐day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment
Myocardial infarction (MI) is the leading cause of death in Western countries. Epidemiological studies show acute MI to be more preva- lent in the morning and to be associated with a poorer outcome in terms of mortality and recovery. The mechanisms behind …
Publication
Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs
Treatment options for patients with hepatocellular carcinoma (HCC) are limited, in particular in advanced and drug resistant HCC. MicroRNAs (miRNA) are non-coding small RNAs that are emerging as novel drugs for the treatment of cancer. The aim of this …
Publication
Noninvasive Contrast-Enhanced Ultrasound Molecular Imaging Detects Myocardial Inflammatory Response in Autoimmune MyocarditisCLINICAL PERSPECTIVE
Background—Cardiac tests for diagnosing myocarditis lack sensitivity or specificity. We hypothesized that contrast- enhanced ultrasound molecular imaging could detect myocardial inflammation and the recruitment of specific cellular subsets of the …
Publication
Left Atrial Volume and Pulmonary Artery Diameter Are Noninvasive Measures of Age- Related Diastolic Dysfunction in Mice
Impaired cardiac diastolic function occurs with aging in many species and may be difficult to measure noninvasively. In humans, left atrial (LA) volume is a robust measure of chronic diastolic function as the LA is exposed to increased left ventricular …
Publication
Asymmetric pulsation of rat carotid artery bifurcation in three-dimension observed by ultrasound imaging
Abstract The arterial structure cyclically fluctuates in three-dimensions (3-D) caused by pulsatile blood flow. The evaluation of arterial wall motion and hemodynam- ics contributes to early diagnosis of carotid atherosclerosis. Ultrasound is one of the …
Publication
Smooth muscle FGF/TGFbeta cross talk regulates atherosclerosis progression
The conversion of vascular smooth muscle cells (SMCs) from contractile to proliferative phenotype is thought to play an important role in atherosclerosis. However, the contribution of this process to plaque growth has never been fully defined. In this …
Publication
Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores
To determine whether hepatic de- pletion of vitamin A (VA) stores has an effect on the postnatal heart, studies were carried out with mice lacking liver retinyl ester stores fed either a VA-sufficient (LRVAS) or VA-deficient (LRVAD) diet (to deplete …
Publication
Chronic plus binge ethanol feeding induces myocardial oxidative stress, mitochondrial and cardiovascular dysfunction and steatosis
Alco- holic cardiomyopathy in humans develops in response to chronic excessive alcohol consumption; however, good models of alcohol- induced cardiomyopathy in mice are lacking. Herein we describe mouse models of alcoholic cardiomyopathies induced by …