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Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture
Previous studies have demonstrated a significantly lower level of Hand1 in ischemic cardiomyopathy than in normal heart tissue. The role of decreased Hand1 in myocardial infarction remains unclear. This study was designed to investigate the effects of …
Publication
Myocardial Ischemia/Reperfusion impairs neurogenesis and hippocampal-dependent learning and memory
The incidence of cognitive impairment in cardiovascular disease (CVD) patients has increased, adversely impacting quality of life and imposing a significant economic burden. Brain imaging of CVD patients has detected changes in the hippocampus, a brain …
Publication
Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies
Tumor hypoxia is known to be one of critical reasons that limit the efficacy of cancer therapies, particularly photodynamic therapy (PDT) and radiotherapy (RT) in which oxygen is needed in the process of cancer cell destruction. Herein, taking advantages …
Publication
In vivo photoacoustic flowmetry at depths of the diffusive regime based on saline injection
We propose a saline injection-based method to quantify blood flow velocity in vivo with acoustic-resolution photoacoustic tomography. By monitoring the saline–blood interface propagating in the blood vessel, the flow velocity can be resolved. We first …
Publication
Accelerated Blood Clearance Phenomenon Reduces the Passive Targeting of PEGylated Nanoparticles in Peripheral Arterial Disease
Peripheral arterial disease (PAD) is a leading global health concern. Due to limited imaging and therapeutic options, PAD and other ischemia-related diseases may benefit from the use of long circulating nanoparticles as imaging probes and/or drug delivery …
Publication
Narrow Absorption NIR Wavelength Organic Nanoparticles Enable Multiplexed Photoacoustic Imaging
Photoacoustic (PA) imaging is an emerging hybrid optical- ultrasound based imaging technique that can be used to visualize optical absorbers in deep tissue. Free organic dyes can be used as PA contrast agents to concurrently provide additional …
Publication
Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging
Gold nanoparticles (AuNP) have been proposed for many applications in medicine. Although large AuNP (> 5.5??nm) are desirable for their longer blood circulation and accumulation in diseased tissues, small AuNP …
Publication
Multimodal near-infrared-emitting PluS Silica nanoparticles with fluorescent , photoacoustic , and photothermal capabilities
Purpose: The aim of the present study was to develop nanoprobes with theranostic features, including – at the same time – photoacoustic, near-infrared (NIR) optical imaging, and pho- tothermal properties, in a versatile and stable core–shell …
Publication
Lung ultrasound is a reliable method for evaluating extravascular lung water volume in rodents
BACKGROUND: Lung ultrasound (LUS) can diagnose extravacular lung water (EVLW) through the visualization of B lines in both humans and large animals. However, there are no published data on the use of ultrasound to detect EVLW in rats, the gold standard to …
Publication
Postnatal Cardiovascular Consequences in the Offspring of Pregnant Rats Exposed to Smoking and Smoking Cessation Pharmacotherapies
Approximately 20% of pregnant women smoke despite intentions to quit. Smoking cessation drugs, such as nicotine replacement therapy (NRT) and bupropion, are recommended treatments. Adverse cardiovascular outcomes in offspring have raised concerns about …