Multiscale molecular engineering co-modulated dual-mode ratiometric probe for monitoring tumor-associated macrophage repolarization …

Carrier-free nanoparticles have attracted significant interest owing to their exceptional drug-loading efficiency, simple preparation, and good biosafety. Inspired by the synergism and attenuation strategy of natural products, carrier-free nanoparticles …

Ultrasound-Guided Photoacoustic Monitoring of Vascular Ischemia in Implant-Induced Skin Necrosis …

Physical activity and exercise confer health benefits through actions on several physiological systems; however, the mechanisms by which they impact renal health remain poorly understood. Studies show that exercise slows age-related decline in kidney …

Ultrasound imaging and ultrasound-mediated gene and drug delivery are rapidly advancing diagnostic and therapeutic methods; however, their use is often limited by the need for microbubbles, which cannot transverse many biological barriers due to their …

Derivation of ultrasound and electrocardiogram cardiac reference ranges for Mus musculus using the collaborative cross and identification of new cardiac …

In humans and other primates, red blood cells (RBCs) constitutively express high levels of liver-type arginase 1 (Arg1), which regulates systemic L-arginine and nitric oxide (NO) bioavailability, particularly under pathological conditions such as sickle …

Pancreatic cancer is an aggressive disease with a dense fibrotic stroma and is often accompanied by chronic inflammation. Peritumoral inflammation is typically viewed as a reaction to nearby tumor growth. Here, we report that the inflamed pancreatic …

Right ventricular (RV) function under pressure overload (PO) is critical in congenital heart disease outcomes. While moderate left ventricular (LV) pressure-loading has been shown to benefit RV function, the mechanisms and optimal degree of loading remain …

The role of driver gene mutations in sustaining tumor growth at metastatic sites is poorly understood. SMAD4 inactivation is a paradigm of such mutations and a hallmark of pancreatic ductal adenocarcinoma (PDAC). To determine whether metastatic tumors are …