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Publication
fractionated radiotherapy for high- grade gliomas
High-grade gliomas (HGGs; WHO grades III and IV) are invariably lethal brain tumors. Low-dose hyper-radiosensitivity (HRS) of HGG is a well-established phenomenon in vitro. However, possibly linked to the unavailability of accurate animal models of the …
Publication
In vivo multimodal imaging of hyaluronan-mediated in fl ammatory response in articular cartilage
Objective: One driving factor in the progression to posttraumatic osteoarthritis (PTOA) is the perpetu- ation of the inflammatory response to injury into chronic inflammation. Molecular imaging offers many opportunities to complement the sensitivity of …
Publication
Journal of Molecular and Cellular Cardiology Ventricular SK2 upregulation following angiotensin II challenge : Modulation by p21-activated kinase-1
Effects of hypertrophic challenge on small-conductance, Ca2+-activated K+ (SK2) channel expression were explored in intact murine hearts, isolated ventricular myocytes and neonatal rat cardiomyocytes (NRCMs). An established experimental platform applied …
Publication
Acidic TME-Responsive Nano-Bi 2 Se 3 @ MnCaP as a NIR- II-Triggered Free Radical Generator for Hypoxia-Irrelevant Phototherapy with High Specificity and Immunogenicity
Here, acidic tumor microenvironment (TME)-responsive nano-Bi2 Se3 @MnCaP, as a near-infrared-II (NIR-II) biowindow-triggered free radical generator for hypoxia-irrelevant phototherapy, is elaborately developed by biomimetic mineralization of MnCaP onto 2, …
Publication
Integrative Cardiovascular Physiology and Pathophysiology Protein tyrosine phosphatase receptor- f 1 deletion triggers defective heart morphogenesis in mice and zebra fi sh
Protein tyrosine phosphatase receptor-f1 (PTPRZ1) is a transmembrane tyrosine phosphatase receptor highly expressed in em- bryonic stem cells. In the present work, gene expression analyses of Ptprz1?/? and Ptprz1þ / þ mice endothelial cells and hearts …
Publication
Ultrasound Scattering From Cell-Pellet Biophantoms and Ex Vivo Tumors Provides Insight Into the Cellular Structure Involved in Scattering
The histologically identifiable cellular struc- ture(s) involved in ultrasonic scattering is(are) yet to be uniquely identified. The study quantifies six possible cel- lular scattering parameters, namely, cell and nucleus radii and their respective cell …
Publication
Detection and Characterization of Sentinel Lymph Node by Ultrasound Molecular Imaging with B7 ‑ H3 ‑ Targeted Microbubbles in Orthotopic Breast Cancer Model in Mice
Purpose: Accurate identification and assessment of sentinel lymph node (SLN) using noninvasive imag- ing methods can play a vital role in tumor staging, surgical planning, and prognostic evaluation. In this study, we assessed the efficacy of …
Publication
Plasma metabolomics-based reveals the treatment mechanism of ShenGui capsule for application to coronary heart disease in a rat model
Shen Gui capsule (SGC) has been demonstrated to have a significant treatment effect for coronary heart disease (CHD). Nevertheless, the holistic therapeutic mechanism of SGC in vivo remain poorly interpreted. We aimed to systematically explore the …
Publication
Liver steatosis is a component of the hepatocardiorenal syn- drome provoked by a high-lipid diet and activation of Ang II pathways in rats
Overweight/obesity is a growing pandemic nowadays that affects many organs and tis- sues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver …
Publication
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy
Recombinant human growth hormone (rhGH), widely used in clinical studies, exerts protective effects against cardiac damage. Here, we investigated the effects and mechanisms underlying the effects of rhGH on cardiac functions in db/db mice. C57BL/6J and …