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Hydration State and Hyaluronidase Treatment Significantly Affect Porcine Vocal Fold Biomechanics
Objectives: The understanding of vocal fold hydration state, including dehydrated, euhydrated, rehydrated tissue, and how hydration affects vocal fold biomechanical properties is still evolving. Although clinical observations support the benefits of …
Publication
Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction
Doxorubicin (Dox)-induced cardiotoxicity could lead to dilated cardiomyopathy and heart failure. Our previous study reported the protective effects of Klotho against hyperglycemia-induced cardiomyopathy. We investigated whether Klotho alleviated …
Publication
Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure
A hallmark of impaired myocardial energetics in failing hearts is the downregulation of the creatine kinase (CK) system. In heart failure patients and animal models, myocardial phosphocreatine content and the flux of the CK reaction are negatively …
Publication
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling
Heart failure is one of the leading causes of death worldwide. A stimulated heart undergoes either adaptive physiological hypertrophy, which can maintain a nor- mal heart function, or maladaptive pathological remodeling, which can deteriorate heart …
Publication
DBA/1 mice displays equivalent cardiac function to C57BL/6J mice
NEW FINDINGS: What is the central question of this study? Do normal adult DBA/1 mice have cardiac function and performance equal to those of C57BL/6J mice? What is the main finding and its importance? Male adult DBA/1 mice show equivalent cardiac function …
Publication
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms
Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of abdominal aortic aneurysms (AAAs). This study has addressed the notion that NET components might serve as AAA biomarkers or novel targets of AAA therapy. Thus, parameters of …
Publication
Suppression of hypoxia‐inducible factor 1α by low‐molecular‐ weight heparin mitigates ventilation‐induced diaphragm dysfunction in a murine endotoxemia model
Mechanical ventilation (MV) is required to maintain life for patients with sepsis‐related acute lung injury but can cause diaphragmatic myotrauma with muscle damage and weakness, known as ventilator‐induced diaphragm dysfunction (VIDD). Hypoxia‐inducible …
Publication
Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis
Adenylate kinase2 (AK2) catalyzes trans-compartmental nucleotide exchange, but the functional implications of this mitochondrial intermembrane isoform is only partially understood. Here, transgenic AK2−/− null homozygosity was lethal early in embryo, …
Publication
Soluble epoxide hydrolase in aged female mice and human explanted hearts following ischemic injury
Myocardial infarction (MI) accounts for a significant proportion of death and morbidity in aged individuals. The risk for MI in females increases as they enter the peri-menopausal period, generally occurring in middle-age. Cytochrome (CYP) 450 metabolizes …
Publication
Nlrp3 Deficiency Alleviates Angiotensin II-Induced Cardiomyopathy by Inhibiting Mitochondrial Dysfunction
Inflammation has been considered a key component in the pathogenesis and progression of angiotensin II- (Ang II-) induced cardiac hypertrophy and related cardiomyopathy. As a vital mediator of inflammation, the role of the Nlrp3 inflammasome in Ang …