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NOX1 mediates metabolic heart disease in mice and is upregulated in monocytes of humans with diastolic dysfunction
Aims: Microvascular inflammation plays an important role in the pathogenesis of diastolic dysfunction (DD) and metabolic heart disease. NOX1 is expressed in vascular and immune cells and has been implicated in the vascular pathology of metabolic disease. …
Publication
Displacement Patterns in Magnetomotive Ultrasound Explored by Finite Element Analysis
Magnetomotive ultrasound is an emerging technique that enables detection of magnetic nanoparticles. This has implications for ultrasound molecular imaging, and potentially addresses clinical needs regarding determination of metastatic infiltration of the …
Publication
Role of plakophilin-2 expression on exercise-related progression of arrhythmogenic right ventricular cardiomyopathy: a translational study
Aims Exercise increases arrhythmia risk and cardiomyopathy progression in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients, but the mechanisms remain unknown. We investigated transcriptomic changes caused by endurance training in mice …
Publication
A mechanistic basis for the malignant progression of salivary gland tumors
Salivary gland tumors are diverse neoplasms, likely reflecting differences in the tissue- and cell-of-origin. 80%–90% of tumors arising in the sublingual gland (SLG) are malignant, whereas the other major glands often form benign tumors. Owing to the lack …
Publication
Huoxin pill prevents acute myocardial ischaemia injury via inhibition of Wnt/β‑catenin signaling
Myocardial infarction (MI) is one of the leading causes of death worldwide, and due to the widespread and irreversible damage caused, new therapeutic treatments are urgently needed in order to limit the degree of ischaemic damage following MI. Aberrant …
Publication
Schisandrin A protects against isoproterenol-induced chronic heart failure via miR-155
Schisandrin A (Sch A) has a protective effect on cardiomyocytes. Circulating miR-155 levels are related to chronic heart failure (CHF). The present study aimed to clarify the role and the molecular mechanism of Sch A in CHF. C57BL/6JGpt mice were used for …
Publication
Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment
Rationale: Tailored inflammation control is badly needed for the treatment of kinds of inflammatory diseases, such as atherosclerosis. IL-10 is a potent anti-inflammatory cytokine, while systemic and repeated delivery could cause detrimental side-effects …
Publication
G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction
GTPase-activating SH3 domain-binding protein 2 (G3BP2) is a mediator that responds to environmental stresses through stress granule formation and is involved in the progression of chronic diseases. However, no studies have examined the contribution of …
Publication
Effect of aging and sex on cardiovascular structure and function in wildtype mice assessed with echocardiography
This study employed traditional and advanced echocardiographic techniques to assess comprehensively age- and sex-related changes in cardiovascular structure and function in wildtype (WT) mice. Forty-five normal adult wildtype mice were apportioned to …
Publication
Brain Delivery of Curcumin Through Low-Intensity Ultrasound-Induced Blood – Brain Barrier Opening via Lipid-PLGA Nanobubbles
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder. Owing to the presence of blood–brain barrier (BBB), conventional pharmaceutical agents are difficult to the diseased nuclei and exert their action to inhibit or delay the …