Search
Publication
DLL1 orchestrates CD8+ T cells to induce long-term vascular normalization and tumor regression
The immunosuppressive and hypoxic tumor microenvironment (TME) remains a major obstacle to impede cancer immunotherapy. Here, we showed that elevated levels of Delta-like 1 (DLL1) in the breast and lung TME induced long-term tumor vascular normalization …
Publication
HIGH FREQUENCY ULTRASONOGRAPHY: RELIABLE TOOL TO MEASURE SKIN FIBROSIS IN SSC? A systematic literature review and additional pilot study
Objectives: To investigate the reliability of high frequency ultrasound (HFUS) in measuring skin fibrosis in systemic sclerosis (SSc). Methods: First, a systematic review (according to PRISMA) was conducted to identify studies that documented HFUS' …
Publication
In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops
Corneal neovascularization (CNV) compromises corneal avascularity and visual acuity. Current clinical visualization approaches are subjective and unable to provide molecular information. Photoacoustic (PA) imaging offers an objective and non-invasive way …
Publication
Dimethyl fumarate preserves left ventricular infarct integrity following myocardial infarction via modulation of cardiac macrophage and fibroblast oxidative metabolism
Myocardial infarction (MI) is one of the leading causes of mortality and cardiovascular disease worldwide. MI is characterized by a substantial inflammatory response in the infarcted left ventricle (LV), followed by transition of quiescent fibroblasts to …
Publication
Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice
factors (Cdkn1a, FoxO3, a-catenin). The predicted downstream effects include a decrease in heart damage, and increased arrhythmia, angiogenesis, and cardiogenesis. There were no significant sex-dependent differences in the AVF-stimulated cardiac …
Publication
Senolytic agents lessen the severity of abdominal aortic aneurysm in aged mice
Age is a major risk factor for abdominal aortic aneurysm (AAA), for which treatment options are limited to surgical intervention for large AAA and watchful waiting for small aneurysms. However, the factors that regulate the expansion of aneurysms are …
Publication
Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: Evidence from a novel CARNS1 knockout rat model
Histidine-containing dipeptides (HCDs) are abundantly expressed in striated muscles. Although important properties have been ascribed to HCDs, including H+ buffering, regulation of Ca2+ transients and protection against oxidative stress, it remains …
Publication
Influence of serotonin 5-HT4 receptors on responses to cardiac stressors in transgenic mouse models
The current study aimed to deepen our knowledge on the role of cardiac 5-HT4 receptors under pathophysiological conditions. To this end, we used transgenic (TG) mice that overexpressed human 5-HT4a receptors solely in cardiac myocytes (5-HT4-TG mice) and …
Publication
Evidences for the mechanism of Shenmai injection antagonizing doxorubicin-induced cardiotoxicity
Background: Doxorubicin (DOX) is a widely used antitumor drug. However, its clinical application is limited for its serious cardiotoxicity. The mechanism of DOX-induced cardiotoxicity is attributed to the increasing of cell stress in cardiomyocytes, then …
Publication
Scaled reassigned spectrograms applied to linear transducer signals
This study evaluates the applicability of scaled reassigned spectrograms (ReSTS) on ultrasound radio frequency data obtained with a clinical linear array ultrasound transducer. The ReSTS’s ability to resolve axially closely spaced objects in a phantom is …