a b s t r a c t Takotsubo cardiomyopathy (TCM) is characterized by transient left ventricular apical ballooning with the absence of coronary occlusion, which is an acute cardiac syndrome with substantial morbidity and mortality. It was reported that …

While the mortality rate associated with sepsis in children has fallen over the years, it still remains unacceptably high. The development of both acute cardiac dysfunction and acute kidney injury during severe sepsis is categorized as type 5 cardiorenal …

Inflammation resolution is important for scar formation following myocardial infarction (MI) and requires the coordinated actions of macrophages and fibroblasts. In this study, we hypothesized that exogenous interleukin-10 (IL-10), an anti-inflammatory …

The myocardial response to pressure overload involves coordination of multiple transcriptional, post- transcriptional, and metabolic cues. The previous studies show that one such metabolic cue, O-GlcNAc, is elevated in the pressure-overloaded heart, and …

Mid-Gestational mouse embryo imaged with B-Mode, with major structures labeled. … … Mouse Embryo …

Selective treatments for myocardial infarction (MI) induced cardiac fibrosis are lacking. In this study,\r\nwe focus on the therapeutic potential of a synthetic cardio-protective agent named ZYZ-168 towards\r\nMI-induced cardiac fibrosis and try to reveal …

BACKGROUND The PGC-1α/PPAR axis has been proposed as a potential therapeutic target for several metabolic disorders. The aim was to evaluate the efficacy of the pan-PPAR agonist, bezafibrate, in tafazzin knockdown mice (TazKD), a mouse model of Barth …

Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial …

Acute myocardial infarction (AMI) has a high incidence and causes severe consequences. Induced plu- ripotent stem (iPS) cells derives from patient’s own cells and has become one research focus for treating cardiovas- cular disease. The role and function …

In addition to their anti-bacterial action, tetracyclines also have complex biological effects, including the modification of mitochondrial protein synthesis, metabolism and gene-expression. Long-term clinical studies have been performed using …