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Maternal B cell signaling orchestrates fetal development in mice
B cell participation in early embryo/fetal development and the underlying molecular pathways have not been explored. To understand whether maternal B cell absence or impaired signaling interferes with placental and fetal growth, we paired CD19-deficient …
Publication
Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model
Speckle tracking echocardiography (STE) enables early diagnosis of myocardial damage by evaluating myocardial strain. We aimed to study sequential changes in structural and ventricular functional parameters during Chagas disease (CD) natural history in an …
Publication
Ubiquitin ligase Wwp1 gene deletion attenuates diastolic dysfunction in pressure-overload hypertrophy
Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and accompanied by abnormal extracellular matrix (ECM) accumulation. The E3 ubiquitin ligase WWP1 is a fundamental …
Publication
Pulmonary Hypertension in Obese Mice Is Accompanied by a Reduction in PPAR-γ Expression in Pulmonary Artery
Obesity and insulin resistance (IR) are well-studied risk factors for systemic cardiovascular disease, but their impact on pulmonary hypertension (PH) is not well clarified. This study aims to investigate if diet-induced obesity induces PH and if …
Publication
Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods
Detection and removal of bladder cancer lesions at an early stage is crucial for preventing tumor relapse and progression. This study aimed to develop a new technological platform for the visualization of small and flat urothelial lesions of high-grade …
Publication
Ultrasound Evaluation of Peripheral Nerve Trauma
Purpose of Review: The use of high-frequency ultrasound has increased dramatically in musculoskeletal and neuromuscular applications in recent years. This article reviews more recent innovation in high-frequency ultrasound and the relative value of use in …
Publication
Deficiency in DDR1 Induces Pulmonary Hypertension and Impaired Alveolar Development
Deficiency in DDR1 Induces Pulmonary Hypertension and Impaired Alveolar Development …
Publication
Comprehensive Ultrasound Imaging of Right Ventricular Remodeling Under Surgically Induced Pressure Overload in Mice
This study reports a new methodology for right heart imaging by ultrasound in mice under right ventricular (RV) pressure overload. Pulmonary artery constriction (PAC) or sham surgeries were performed on C57BL/6 male mice at 8 weeks of age. Ultrasound …
Publication
High-frequency ultrasound-guided intrathecal injections in a young mouse model: Targeting the central nervous system in drug delivery
Background: Intrathecal injections provide important access to the central nervous system for delivery of anes- thetic, analgesic or chemotherapeutic drugs that do not otherwise cross the blood-brain barrier. The adminis- tration of drugs via this route …
Publication
In vivo monitoring of venous thrombosis in mice
Background: Venous thrombosis (VT) is an important cause of morbidity and mortality in clinical medicine. Animal models studying venous thrombosis are scarce and, in most cases, very crude and rely on sacrificing the animals to excise formed thrombi. …