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Metoprolol attenuates intracerebral hemorrhage-induced cardiac damage by suppression of sympathetic overactivity in mice
The high rates of mortality and disability resulting from intracerebral hemorrhage (ICH) are closely related to subsequent cardiac complications. The mechanisms underlying ICH-induced cardiac dysfunction are not fully understood. In this study, we …
Publication
Intravenous Delivery of Lung-Targeted Nanofibers for Pulmonary Hypertension in Mice
Pulmonary hypertension is a highly morbid disease with no cure. Available treatments are limited by systemic adverse effects due to non-specific biodistribution. Self-assembled peptide amphiphile (PA) nanofibers are biocompatible nanomaterials that can be …
Publication
Multi-modality imaging assisted fluorescence-guided resection of glioblastoma: Case report
Introduction: Glioblastoma is a highly malignant and infiltrative brain tumor, with a median overall survival of about 15 months. Gross-total resection using 5-aminolevulinic acid (5-ALA) assisted fluorescence-guided tumor resection has been shown to …
Publication
Automatic threshold selection algorithm to distinguish a tissue chromophore from the background in photoacoustic imaging
The adaptive matched filter (AMF) is a method widely used in spectral unmixing to classify different tissue chromophores in photoacoustic images. However, a threshold needs to be applied to the AMF detection image to distinguish the desired tissue …
Publication
Renal neoplasms in tuberous sclerosis mice are neurocristopathies
Tuberous sclerosis (TS) is a rare disorder exhibiting multi-systemic benign neoplasms. We hypothesized the origin of TS neoplastic cells derived from the neural crest given the heterogeneous ecto-mesenchymal phenotype of the most common TS neoplasms. To …
Publication
Bioinspired therapeutic platform based on extracellular vesicles for prevention of arterial wall remodeling in hypertension
Arterial stiffness due to the vessel remodeling is closely linked to raised blood pressure, and its physiopathologic mechanism is still not fully understood. We here aimed to explore whether extracellular vesicle (EV) mediated intercellular communication …
Publication
Photoacoustic imaging for the monitoring of local changes in oxygen saturation following an adrenaline injection in human forearm skin
Clinical monitoring of blood oxygen saturation (sO 2) is traditionally performed using optical techniques, such as pulse oximetry and diffuse reflectance spectroscopy (DRS), which lack spatial resolution. Photoacoustic imaging (PAI) is a rapidly …
Publication
Alarin alleviated cardiac fibrosis via attenuating oxidative stress in heart failure rats
The present study was to explore whether alarin could alleviate heart failure (HF) and attenuate cardia fibrosis via inhibiting oxidative stress. The fibrosis of cardiac fibroblasts (CFs) was induced by angiotensin (Ang) II. HF models were induced by …
Publication
Inhibition of Interleukin-21 prolongs the survival through the promotion of wound healing after myocardial infarction
Ly6Clow macrophages promote scar formation and prevent early infarct expansion after myocardial infarction (MI). Although CD4+ T cells influence the regulation of Ly6Clow macrophages after MI, the mechanism remains largely unknown. Based on the hypothesis …
Publication
Interferon γ neutralization reduces blood pressure, uterine artery resistance index, and placental oxidative stress in placental ischemic rats
Preeclampsia (PE) is characterized by maternal hypertension, intrauterine growth restriction, and increased cytolytic natural killer cells (cNKs), which secrete interferon γ (IFNγ). However, the precise role of IFNγ in contributing to PE pathophysiology …