The superior mesenteric artery (SMA), originating from the abdominal aorta, provides blood supply for the spleen, pancreas, intestine, and part of the colon. Here, we present a protocol for studying the SMA in the same mouse by combining non-invasive …

Abdominal aortic aneurysm (AAA) is a prevalent degenerative disease characterized by an exacerbated inflammation and destructive vascular remodeling. Unfortunately, effective pharmacological tools for the treatment of this disease remain a challenge. …

Many cardiovascular events are triggered by fibrous cap rupture of an atherosclerotic plaque in arteries. However, cap rupture, including the impact of the cap's structural components, is poorly understood. To obtain better mechanistic insights in a …

Nasopharyngeal carcinoma (NPC), a malignancy highly prevalent in East and Southeast Asia, is primarily treated with radiotherapy (RT). However, hypoxia-induced radioresistance presents a significant challenge. Nanozymes, nanomaterials with catalase-like …

This study investigates the synergistic inhibitory effects of combining the stimulator of interferon genes (STING) agonist cyclic diadenylate monophosphate (c-di-AMP) and ginsenoside RG3 on cisplatin (DDP)-resistant gastric cancer (GC) cells. The …

Background: Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral imaging emerges as a promising modality due to its high spatial resolution and signal stability. However, its clinical …

Background: Historically, lymphovenous bypass (LVB) is reserved for patients with early-stage lymphedema owing to the difficulty in identifying functional lymphatic vessels using indocyanine green (ICG) lymphography in patients with advanced lymphedema. …

Background: Thermosensitive hydrogels are promising for sustained immunosuppressive drug release, but the efficacy of a single local injection of mixed thermosensitive hydrogel-carried tacrolimus in preventing rejection and maintaining allograft survival …

The excessive extracellular matrix (ECM) in solid tumors significantly inhibits the deep penetration and homogeneous distribution of nanodrugs, which greatly reduces the therapeutic efficacy. In the present work, an injectable polyelectrolyte hydrogel …

Background: Metabolic syndrome represents a pancreatic ductal adenocarcinoma (PDAC) risk factor. Metabolic alterations favor PDAC onset, which occurs early upon dysmetabolism. Pancreatic neoplastic lesions evolve within a dense desmoplastic stroma, …