ABSTRACT Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune related adverse events, most likely due to the breadth of the induced …

Viral myocarditis (VMC) is an inflammation of the myocardium closely associated with Coxsackievirus B3 (CVB3) infection. V?1+??T cells, one of early cardiac infiltrated innate population, were reported to pro- tect CVB3 myocarditis while the precise …

Locomotion is an essential animal behavior used for translocation. The spinal cord acts as key executing center, but how it coordinates many body parts located across distance remains poorly under- stood. Here we employed mouse genetic and viral …

Introduction Bcl-2–associated athanogene 3 (BAG3) is a 575–amino acid protein that is highly conserved in nature (1). First identified by its ability to bind Bcl-2, BAG3 is expressed most abundantly in the heart and skeletal muscle and in many cancers. …

Abstract Duchennemuscular dystrophy (DMD) is a severe, degenerativemuscle disease caused by dystrophin mutations. The mdx mouse is a widely used animal model of DMD. The mdx diaphragmmuscle most closely recapitulates key features ofDMDmuscles, including …

B-Mode image of the aortic arch of a mouse, acquired using the Vevo 3100 system. … … Mouse Aortic Arch …

Abstract Background: The morbidity of myocardial infarction is keeping raise in this decade. Because of high safety and operability , percutaneous coronary intervention(PCI) has been used to conquer this disease for more than 20 years.An important …

RATIONALE Transforming Growth Factor-β (TGFβ) ligands signal via type I and type II serine-threonine kinase receptors to regulate broad transcriptional programs. Excessive TGFβ-mediated signaling is implicated in the pathogenesis of pulmonary arterial …

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. This study was aimed at evaluating the efficacy of AR-42 (formerly OSU-HDAC42), a novel histone deacetylase (HDAC) inhibitor currently in …

Abstract—Inflammation has been implicated in myocardial infarction (MI). MDM2 associates with n- uclear factor-κB(NF-κB)-mediated inflammation. However, the role ofMDM2 inMI remains unclear. This study aimed to evaluate the impacts ofMDM2 inhibition on …