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Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure
Rationale: Circumstantial evidence links the development of heart failure to post-translational modifications of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that Kac compromises mitochondrial performance …
Publication
A bi-layered tubular scaffold for effective anti-coagulant in vascular tissue engineering
Acute coagulation is one of the vexed problems in transplantation of small-diameter artificial blood vessel. Three-dimensional porous heparin-modified gelatin (Gel)@chitosan (CS) tubular scaffold were successfully acquired by using the method of …
Publication
Myocardial infarction accelerates breast cancer via innate immune reprogramming
Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity1 or surgery2, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to …
Publication
The novel DPP-BDT nanoparticles as efficient photoacoustic imaging and positron emission tomography agents in living mice
Background: Molecular imaging is of great benefit to early disease diagnosis and timely treatment. One of the most striking innovations is the development of multimodal molecular imaging technology, which integrates two or more imaging modalities, largely …
Publication
Exosomal CircHIPK3 Released from Hypoxia-Induced Cardiomyocytes Regulates Cardiac Angiogenesis after Myocardial Infarction
Exosomes play critical roles in mediating cell-to-cell communication by delivering noncoding RNAs (including miRNAs, lncRNAs, and circRNAs). Our previous study found that cardiomyocytes (CMs) subjected to hypoxia released circHIPK3-rich exosomes to …
Publication
Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction
Phycotoxins and toxic microalgae have been investigated since early 1990s in coastal waters of China. Paralytic shellfish poisoning (PSP) pollution has been increasing year by year, which seriously harmed the coastal waters in South China Sea in 1990s, in …
Publication
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice
While the neuronal underpinnings of autism spectrum disorder (ASD) are being unraveled, vascular contributions to ASD remain elusive. Here, we investigated postnatal cerebrovascular development in the 16p11.2df/+ mouse model of 16p11.2 deletion ASD …
Publication
Lin28a up-regulation is associated with the formation of restenosis via promoting proliferation and migration of vascular smooth muscle cells
To explore the potential role of Lin28a in the development of restenosis after percutaneous transluminal angioplasty, double-balloon injury surgery and mono-balloon injury surgery were used to establish restenosis and atherosclerosis models, respectively, …
Publication
In vivo photoacoustic guidance of stem cell injection and delivery for regenerative spinal cord therapies
Significance: Stem cell therapies are of interest for treating a variety of neurodegenerative diseases and injuries of the spinal cord. However, the lack of techniques for longitudinal monitoring of stem cell therapy progression is inhibiting clinical …
Publication
Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice
The ever-increasing incidence of obesity and related disorders impose serious challenges on public health worldwide. Brown adipose tissue (BAT) has strong capacity for promoting energy expenditure and has shown great potential in treating obesity. …