Although urgently needed in clinical practice, a cardioprotective therapeutic approach against myocardial ischemia/ reperfusion injury remains to be established. Remote ischemic preconditioning (rIPC) and ischemic preconditioning (IPC) represent promising …

Background The aging heart is characterized by cellular and molecular changes leading to a decline in physiologic function and cardiac remodeling, specifically the development of myocyte hypertrophy and fibrosis. Transient receptor potential vanilloid 2 …

Rationale: Phosphodiesterase 2 (PDE2) is a dual substrate esterase, which has the unique property to be stimulated by cGMP, but primarily hydrolyses cAMP. Myocardial PDE2 is upregulated in human heart failure (HF), but its role in the heart is unknown. …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nu- clear lamina alterations, severe cardiovascular pathology, and pre- mature death. Prelamin A alterations also occur in …

Congestive heart failure is one of the leading causes of disability in long-term survivors of cancer. The anthracycline antibiotic doxo- rubicin (DOX) is used to treat a variety of cancers, but its utility is limited by its cumulative cardiotoxicity. As …

BACKGROUND The underlying molecular aetiology of congenital heart defects is largely unknown. The aim of this study was to explore the genetic basis of non-syndromic severe congenital valve malformations in two unrelated families. METHODS Whole-exome …

Background, Motivation and Objective Bolus & burst (B&B) is a method for quantitative ultrasound perfusion analysis combining bolus tracking and burst replenishment. Estimation of perfusion parameters is based on blind deconvolution where the measured …

BACKGROUND We have recently found that 3 repeated doses (12×106each) of c-kitPOScardiac progenitor cells (CPCs) were markedly more effective than a single dose of 12×106cells in alleviating postinfarction left ventricular dysfunction and remodeling. …

We tested the hypothesis that melatonin prevents brain death (BD) tissue extract (BDEX)-induced cardiac damage by suppressing inflammatory damage-associated molecular pattern (DAMP) signaling in rats. Six hours after BD induction, levels of a DAMP …

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: Quercetin, a flavonoid, has been reported to ameliorate cardiovascular diseases, such as cardiac hypertrophy. However, the mechanism is not completely understood. In this …