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Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants
Preterm infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH) have accelerated lung aging and poor long-term outcomes. Klotho is an antiaging protein that modulates oxidative stress, angiogenesis and fibrosis. Here we test the …
Publication
Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer
Background Radiation therapy (RT) has the potential to enhance the efficacy of immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape of treatments for many cancers, but not yet for pancreatic ductal adenocarcinoma …
Publication
Inter-Tumor Heterogeneity-Melanomas Respond Differently to GM-CSF-Mediated Activation
Granulocyte-monocyte colony stimulating factor (GM-CSF) is used as an adjuvant in various clinical and preclinical studies with contradictory results. These were attributed to opposing effects of GM-CSF on the immune or myeloid systems of the treated …
Publication
Pyrroloquinoline quinone can prevent chronic heart failure by regulating mitochondrial function
Background: Myocardial mitochondrial dysfunction is the leading cause of chronic heart failure (CHF). Increased reactive oxygen species (ROS) levels, disruption of mitochondrial biogenesis and mitochondrial Ca2+([Ca2+]m) homeostasis and reduction of the …
Publication
Enhanced optical imaging properties of lipid nanocapsules as vehicles for fluorescent conjugated polymers
Conjugated polymer nanoparticles (CPNs) have emerged as highly photostable probes for optical and photoacoustic imaging. However, the aggregation of conjugated polymer (CP) molecules upon nanoparticle formation is associated with fluorescence quenching, …
Publication
Hyaluronan promotes the regeneration of vascular smooth muscle with potent contractile function in rapidly biodegradable vascular grafts
The regeneration of smooth muscle with physiological functions has been a key challenge in vascular tissue engineering. Hyaluronan (HA), as a major component of the extracellular matrix, plays a vital role in regulating tissue injury and repair. In this …
Publication
Visualization of Microvascular Angiogenesis Using Dual-Frequency Contrast-Enhanced Acoustic Angiography: A Review
Cancerous tumor growth is associated with the development of tortuous, chaotic microvasculature, and this aberrant microvascular morphology can act as a biomarker of malignant disease. Acoustic angiography is a contrast-enhanced ultrasound technique that …
Publication
EXPRESS: TMEM16A/ANO1 Inhibitor T16Ainh-A01 Reversed Monocrotaline-induced Rat Pulmonary Arterial Hypertension
Experimental proof that TMEM16A was involved in the development of the monocrotaline (MCT) -induced pulmonary arterial hypertension (PAH) model through ERK1/2 activation, and it is a potential target for PAH treatment. A PAH rat model was established by …
Publication
Targeting the eCIRP/TREM-1 Interaction with a Small Molecule Inhibitor Improves Cardiac Dysfunction in Neonatal Sepsis
Background: Neonatal sepsis and the associated myocardial dysfunction remain a leading cause of infant mortality. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a ligand of triggering receptor expressed on myeloid cells-1 (TREM-1). M3 is …
Publication
Exercise training suppresses Mst1 activation and attenuates myocardial dysfunction in mice with type 1 diabetes
Our study was to test the effects of aerobic exercise on myocardial function in mice with type 1 diabetes and investigate underlying mechanism associated with mammalian sterile 20-like kinase 1 (Mst1). Wild-type (WT) mice and Mst1(-/-) mice were injected …