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Absence of the MFG-E8 gene prevents hypoxia-induced pulmonary hypertension in mice
Pulmonary hypertension (PH) is a chronic vascular disease characterized by elevated pulmonary arterial resistance and vascular remodeling, and chronic hypoxia plays an important role in PH. Milk fat globule-EGF factor 8 (MFG-E8) is a glycoprotein that …
Publication
Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) evolves a complex microenvironment comprised of multiple cell types, including pancreatic stellate cells (PSC). Previous studies have demonstrated that stromal supply of alanine, lipids, and nucleotides supports the …
Publication
Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion
Heart failure (HF) is an increasing global health crisis, affecting 40 million people and causing 50% mortality within 5 years of diagnosis. A fuller understanding of the genetic and environmental factors underlying HF, and novel therapeutic approaches to …
Publication
Dermatology Practical & Conceptual Delayed Tattoo Reaction From Red Dye With Overlapping Clinicopathological Features : Examination With High-Frequency Ultrasound and Line-Field Optical Coherence Tomography
Delayed tattoo reactions include a wide range of clinical presentations and overlapping forms; thus diagnosis can be challenging. We present a case of a delayed tattoo reaction from red …
Publication
Ultra-High Frequency Ultrasound, A Promising Diagnostic Technique: Review of the Literature and Single-Center Experience
Objectives: Ultra-high frequency ultrasonography (UHFUS) is a recently introduced diagnostic technique which finds several applications in diverse clinical fields. The range of frequencies between 30 and 100 MHz allows for high spatial resolution imaging …
Publication
Tongmai Yangxin pill reduces myocardial no-reflow by regulating apoptosis and activating PI3K/Akt/eNOS pathway
Ethnopharmacological relevance: Tongmai Yangxin pill (TMYX) is derived from the Zhigancao decoction recorded in Shang han lun by Zhang Zhongjing during the Han dynasty and was further improved by Professor Ruan Shiyi, a cardiovascular expert at Tianjin …
Publication
MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy
Promoting tumor angiogenesis effectively and specifically to resolve tumor-associated hypoperfusion holds promise for improving pancreatic cancer therapy. Herein, a doxorubicin (DOX) loaded smart liposome, MC-T-DOX, is constructed, that carries …
Publication
Current and future applications of ultrasound imaging in peripheral nerve disorders
Neuromuscular ultrasound (NMUS) is a rapidly evolving technique used in neuromuscular medicine to provide complimentary information to standard electrodiagnostic studies. NMUS provides a dynamic, real time assessment of anatomy which can alter both …
Publication
Transplacental sildenafil rescues lung abnormalities in the rabbit model of diaphragmatic hernia
Introduction The management of congenital diaphragmatic hernia (DH) would benefit from an antenatal medical therapy, which addresses both lung hypoplasia and persistent pulmonary hypertension. We aimed at evaluating the pulmonary effects of sildenafil in …
Publication
Ultrasound measurement of change in kidney volume is a sensitive indicator of severity of renal parenchymal injury
Non-invasive determination of the severity of parenchymal injury in acute kidney injury (AKI) remains challenging. Edema is an early pathological process following injury, which may correlate with changes in kidney volume. The goal of this study was to …