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Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood
Intravascular photoacoustic (IVPA) imaging can characterize atherosclerotic plaque composition on the basis of the optical absorption contrast between different tissue types. Given the high optical absorption of lipid at 1720 nm wavelength, an …
Publication
Ex vivo Characterization of Atherosclerosis using Intravascular Photoacoustic Imaging.
The imaging of plaque composition represents one of the important steps in the interventional management of atherosclerosis. Intravascular photoacoustic (IVPA) imaging has the potential to play a major role in the detection and differentiation of an …
Publication
In vivo imaging of inducible tyrosinase gene expression with an ultrasound array-based photoacoustic system Imaging of gene expression Limitations of optical
In vivo imaging of inducible tyrosinase gene expression with an ultrasound array-based photoacoustic system Imaging of gene expression Limitations of …
Publication
Poster: Development of a combined photoacoustic micro-ultrasound system for estimating blood oxygenation
Photoacoustic (PA) imaging can estimate the spatial distribution of oxygen saturation (sO 2 ) in blood, and be co-registered with B-Mode images of the surrounding anatomy. This study will focus on the development of a PA imaging mode on a commercially …
Publication
Antiangiogenic Cancer Therapy : Monitoring with Molecular US and a Clinically Translatable Contrast Purpose : Methods : Results :
Purpose: Materials and Methods: To develop and test human kinase insert domain receptor (KDR)-targeted microbubbles (MBs) (MB KDR ) for imaging KDR at the molecular level and for monitoring antiangiogenic therapy in a human colon cancer xenograft tumor …
Publication
IFN-beta restricts tumor growth and sensitizes alveolar rhabdomyosarcoma to ionizing radiation.
Ionizing radiation is an important component of multimodal therapy for alveolar rhabdomyosarcoma (ARMS). We sought to evaluate the ability of IFN-beta to enhance the activity of ionizing radiation. Rh-30 and Rh-41 ARMS cells were treated with IFN-beta and …
Publication
Dinitroazetidines are a novel class of anticancer agents and hypoxia-activated radiation sensitizers developed from highly energetic materials.
In an effort to develop cancer therapies that maximize cytotoxicity, while minimizing unwanted side effects, we studied a series of novel compounds based on the highly energetic heterocyclic scaffold, dinitroazetidine. In this study, we report the …
Publication
Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.
The contribution of bone marrow-derived circulating endothelial progenitor cells (CEPs) to tumor angiogenesis has been controversial, primarily because of their low numbers in blood vessels of untreated tumors. We show that treatment of tumor-bearing mice …
Publication
Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer.
PURPOSE: To evaluate noninvasive molecular imaging methods as correlative biomarkers of therapeutic efficacy of cetuximab in human colorectal cancer cell line xenografts grown in athymic nude mice. The correlation between molecular imaging and …
Publication
Assessment of endothelin-A receptor expression in subcutaneous and orthotopic thyroid carcinoma xenografts in vivo employing optical imaging methods.
Endothelin (ET) receptor dysregulation has been described in a number of pathophysiological processes, including cardiovascular disorders, renal failure, and cancer. The aim of this study was to evaluate the expression of the ET-A receptor (ET(A)R) in …