PARP1 and PARP2 dual inhibitors, such as olaparib, have been recently FDA approved for the treatment of advanced breast and ovarian cancers. However, their effects on bone mass and bone metastasis are unknown. Here we show that olaparib increases breast …

Aim: Cardiovascular complication is a major cause of mortality and morbidity in patients with diabetes. Insulin sensitivity loss is a major contributor to the pathogenesis of cardiovascular diseases in diabetes. Based on our previous research, …

Purpose The pro-aging miRNA, miR-34a, is hyperactivated in the cardiac myocardial tissues ofpatients and mice with diabetes, leading to diabetic cardiomyopathy (DCM). Increasing evidence suggests that dihydromyricetin (DHM) can be used to effec- tively …

Endothelial dysfunction is a critical event in vascular inflammation characterized, in part, by elevated surface expression of adhesion molecules such as intercellular adhesion molecule- 1 (ICAM-1). ICAM-1 is heavily N-glycosylated, and like other surface …

Cannabinoids are reported to rescue cocaine- induced seizures (CISs), a severe complication in cocaine users. However, the molecular targets for cannabinoid therapy of CISs remain unclear. Here, we report that the systemic administration of cannabi- noids …

The key challenge for in vivo biosensing is to design biomarker-responsive contrast agents that can be readily detected and monitored by broadly available biomedical imaging modalities. While a range of biosensors have been designed for optical, …

Objective: To study the accuracy and feasibility of very-high resolution ultrasound (VHRU, 25-55 MHz) and conventional high resolution ultrasound (HRU, 12 MHz) in the assessment of common carotid intima-media thickness (IMT) in healthy children between 0 …

Preliminary findings suggest that very-high resolution ultrasound (VHRU, 55 MHz) could differentiate arterial intima layer thickness (IT) non-invasively in vivo. We aimed to validate ultrasound-derived IT measurements and describe a four-line pattern …

Objective: Very-high resolution US (VHRU; 55 MHz) provides improved resolution and could provide non-invasive diagnostic information in GCA of the temporal artery. The objective of this study was to assess the diagnostic utility of VHRU-derived intima …

Background: Non-invasive transcutaneous very-high resolution ultrasound (VHRU, 25-55MHz) has recently been developed to quantify superficial vascular structures in humans. The performance of the method has yet not been evaluated invivo in neonates. The …