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Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing
AIMS The role of uncoupling protein 2 (UCP2) in cardiac adaptation to pressure overload remains unclear. In a classical model of left ventricular pressure overload genetic deletion of UCP2 (UCP2-/-) protected against cardiac hypertrophy and failure. …
Publication
Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy
Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) failure even with optimal medical care. An increase of PM2.5 of 10 …
Publication
Strain mapping from 4D ultrasound reveals complex remodeling in dissecting murine abdominal aortic aneurysms.
Current in vivo abdominal aortic aneurysm imaging approaches tend to focus on maximum diameter but do not measure 3D vascular deformation or strain. Complex vessel geometries, heterogeneous wall compositions, and surrounding structures can all influence …
Publication
Endogenous Interleukin-10 Deficiency Exacerbates Vascular Pathology in Traumatic Cervical Spinal Cord Injury
Although the majority of traumatic spinal cord injuries (SCI) take place at the cervical level, preclinical studies have been disproportionally focused on thoracic insults. With differences in anatomy, physiology and immune response between spinal cord …
Publication
Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function
The homeodomain transcription factor NKX2-5 is known to be essential for both normal heart development and for heart function. But little is yet known about the identities of its downstream effectors or their function during differentiation of cardiac …
Publication
Exercise Reveals Proline Dehydrogenase as a Potential Target in Heart Failure
The benefits of physical activity in cardiovascular diseases have long been appreciated. However, the molecular mechanisms that trigger and sustain the cardiac benefits of exercise are poorly understood, and it is anticipated that unveiling these …
Publication
Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis
Sepsis costs the healthcare system $23 billion annually and has a mortality rate between 10-40%. An early indication of sepsis is the onset of hyperglycemia, which is the result of sepsis-induced insulin resistance in skeletal muscle. Previous …
Publication
Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction
AIM A direct oral anti-coagulant, FXa inhibitor, has been applied to the clinical treatment of myocardial infarction (MI). Experimental studies in mice indicated that FXa inhibitors reduced atherosclerosis and prevented cardiac dysfunction after coronary …
Publication
mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development
Hepatoblastoma (HB) is the most common pediatric liver malignancy. Around 80% of HB demonstrate simultaneous activation of β-catenin and Yes-associated protein 1 (Yap1). The mechanism by which these signaling pathways contribute to HB pathogenesis remain …
Publication
Temporal dynamics of immune response following prolonged myocardial ischemia/reperfusion with and without cyclosporine A
Understanding the dynamics of the immune response following late myocardial reperfusion is critical for the development of immunomodulatory therapy for myocardial infarction (MI). Cyclosporine A (CSA) possesses multiple therapeutic applications for MI, …