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Mesopore-Induced Aggregation of Cobalt Protoporphyrin for Photoacoustic Imaging and Antioxidant Protection of Stem Cells
With the ever‐accelerating development of functional materials design and fabrication, various nanomaterial‐based molecular imaging platforms with improved detectability and functionality have been developed for next‐generation cell tracking technologies …
Publication
Ultrasound molecular imaging as a non-invasive companion diagnostic for netrin-1 interference therapy in breast cancer
In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel netrin-1 interference …
Publication
Ischemic Stroke Increases Heart Vulnerability to Ischemia-Reperfusion and Alters Myocardial Cardioprotective Pathways
Background and Purpose- For years, the relationship between cardiac and neurological ischemic events has been limited to overlapping pathophysiological mechanisms and common risk factors. However, acute stroke may induce dramatic changes in cardiovascular …
Publication
Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
Long non-coding RNAs (lncRNAs) have emerged as a new class of gene expression reg- ulators playing key roles in many biological and pathophysiological processes. Here, we identify cardiac conduction regulatory RNA (CCRR) as an antiarrhythmic lncRNA. CCRR …
Publication
Profile of cardiac lipid metabolism in STZ-induced diabetic mice
BACKGROUND: Lipotoxicity contributes to diabetic myocardial disease. In this study, we investigated the lipid species contributing to lipotoxicity and the relationship with peroxisomal beta-oxidation in the heart of diabetic mice. METHODS: Male C57BL/6 …
Publication
Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice
Background: The vagus nerve is involved in regulating immunity and resolving inflammation. Current strategies aimed at modulating neuroinflammation and cognitive decline, in many cases, are limited and ineffective. Objective: We sought to develop a …
Publication
Epigallocatechin-3 gallate prevents pressure overload-induced heart failure by up-regulating SERCA2a via histone acetylation modification in mice
Heart failure is a common, costly, and potentially fatal condition. The cardiac sarcoplasmic reticulum Ca-ATPase (SERCA2a) plays a critical role in the regulation of cardiac function. Pre- viously, low SERCA2a expression was revealed in mice with heart …
Publication
Serological biomarkers associate ultrasound characteristics of steatohepatitis in mice with liver cancer
Banana is the common name for herbaceous plants of the genus Musa and for the fruit they produce. It is one of the oldest cultivated plants. All parts of the banana plant have medicinal applications: the flowers in bronchitis and dysentery and on ulcers; …
Publication
Exosomal 15-LO2 mediates hypoxia-induced pulmonary artery hypertension in vivo and in vitro
Our previous studies have shown that 15-LO2/15-HETE induced by hypoxia played an important role in pulmonary arterial hypertension (PH). However, the transportations of 15-LO2/15-HETE among the cells remain elusive. In this study, we investigated the …
Publication
Long noncoding RNA Meg3 regulates cardiomyocyte apoptosis in myocardial infarction
Myocardial infarction (MI), with a major process of cardiomyocyte death, remains a leading cause of morbidity and mortality worldwide. To date, it has been shown that lncRNAs play important roles in cardiovascular pathology. However, the detailed studies …