OBJECTIVE:: Non-ablative or mild hyperthermia (HT) has been shown in preclinical (and clinical) studies as a localized radiosensitizer that enhances the tumoricidal effects of radiation. Most preclinical in vivo HT studies use subcutaneous tumor models …

Islet transplantation is superior to extrinsic insulin supplementation in the treating severe Type 1 diabetes. However, its efficiency and longevity are limited by substantial islet loss post-transplantation due to lack of engraftment and vascular supply. …

Introduction: Proper placental function is essential for optimal fetal growth in utero. Placental transfer of nutrients to the fetus can be measured using radiolabelled tracers, but non-radioactive methods have potential advantages. This study aimed to …

Over the past decade, non-invasive preclinical imaging has emerged as an important tool to facilitate biomedical discovery. Not only have the markets for these tools accelerated, but the numbers of peer-reviewed papers in which imaging end points and …

Preeclampsia is a pregnancy-related hypertensive disorder accounting for 14% of global maternal deaths annually. Preeclampsia — maternal hypertension and proteinuria — is promoted by placental ischemia resulting from reduced uteroplacental perfusion. …

Based on their lobule location, hepatocytes display differential gene expression, including pericentral hepatocytes that surround the central vein, which are marked by Wnt-b-catenin signaling. Activating b-catenin mutations occur in a variety of liver …

Cardiomyopathy is a common myocardial disease that can lead to sudden death. However, molecular mechanisms underlying cardiomyopathy remains unclear. Jarid2 is necessary for embryonic heart development, but functions of Jarid2 after birth remains to be …

Rationale: Mutations in the LMNA gene, encoding lamin A/C (LMNA), are responsible for laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in laminopathies. Objective: To gain insights into the molecular pathogenesis of …

Background. Optimal phosphate control is an unmet need in chronic kidney disease (CKD). High serumphosphate increases calcification burden and is associatedwithmortality and cardio- vascular disease inCKD.Nicotinamide (NA) alone or in combi- nation with …

Goats have always been considered very useful animals. Goats success is related to its excellent adaptability to the diicult mountain conditions, extreme weather and low value feed acceptance, versatile habits and high production considering their size. …