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Cardioprotective effects of the novel curcumin analogue C66 in diabetic mice is dependent on JNK2 inactivation
Aim: Diabetic cardiomyopathy is an independent cardiac injury that can develop in diabetic individuals. Our previous study showed that C66, a curcumin analogue, pro- tects against diabetes‐induced cardiac damage. The present study sought to reveal the …
Publication
Rosuvastatin stabilizes atherosclerotic plaques by reducing CD40L overexpression-induced downregulation of P4Hα1 in ApoE−/− mice
Background Cluster of differentiation 40 ligand (CD40L) and rosuvastatin (RSV) affect atherosclerotic plaque stability, but little is known about their roles in extracellular matrix (ECM) production. We investigated the effects of CD40L and RSV on …
Publication
Involvement of MicroRNA-133a in the Protective Effect of Hydrogen Sulfide against Ischemia/Reperfusion-Induced Endoplasmic Reticulum Stress and Cardiomyocyte Apoptosis
Aim: Myocardial ischemia/reperfusion (I/R) injury is a severe trauma that cells undergo and is associated with cardiomyo- cyte apoptosis. Recently, miRNAs have been demonstrated to play an important role in cardiovascular biology and dis- ease. However, …
Publication
Sitagliptin Protects Cardiac Function by Reducing Nitroxidative Stress and Promoting Autophagy in Zucker Diabetic Fatty (ZDF) Rats
Purpose: The purpose of the study is to identify potential mechanisms involved in the cardiac protective effects of sitagliptin in Zucker diabetic fatty (ZDF) rats. Methods and Results: Male non-diabetic lean Zucker rats (Lean) and ZDF rats treated with …
Publication
Remodeling Tumor-Associated Macrophages and Neovascularization Overcomes EGFR T790M -Associated Drug Resistance by PD-L1 Nanobody-Mediated Codelivery
Precision medicine has made a significant breakthrough in the past decade. The most representative success is the molecular targeting therapy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in nonsmall- cell lung cancer (NSCLC) …
Publication
Non-linear Wave Propagation and Safety Standards for Diagnostic Ultrasound Devices
Safety standards for clinical diagnostic ultrasonic devices were developed for use in relatively low- frequency systems (1?10 MHz), under the assumption that non-linear effects would be negligible. This article reviews ways in which neglecting non-linear …
Publication
HDAC6 inhibition protects cardiomyocytes against doxorubicin-induced acute damage by improving α-tubulin acetylation
Doxorubicin (Dox) is an efficacious antineoplastic drug but is limited used for its cardiotoxicity. Histone Deacetylase 6 (HDAC6) has been indicated to participate in cardiomyopathies, however, its role in Dox-induced cardiac injury is largely unknown. In …
Publication
Repurposing simvastatin as a therapy for preterm labor: evidence from preclinical models
Preterm birth (PTB), the leading cause of neonatal morbidity and mortality, urgently requires novel therapeutic agents. Spontaneous PTB, resulting from preterm labor, is commonly caused by intrauterine infection/inflammation. Statins are well-established, …
Publication
Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics
Background-—The Sigma 1 receptor (Sigmar1) functions as an interorganelle signaling molecule and elicits cytoprotective functions. The presence of Sigmar1 in the heart was first reported on the basis of a ligand-binding assay, and all studies to date have …
Publication
A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain
A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain …