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Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice
CD36 is one of the important transporters of long-chain fatty acids (LCFAs) in the myocardium. We previously reported that CD36-deficient patients demonstrate a marked reduction of myocardial uptake of LCFA, while myocardial glucose uptake shows a …
Publication
RET, a Targetable Driver of Pancreatic Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease, affecting about 40,000 individuals in the United States annually. We aimed to characterize the role of RET as a co-driver of pancreas tumorigenesis. To assess the role of RET as a co-driver …
Publication
Integration of Polymerization and Biomineralization as a Strategy to Facilely Synthesize Nanotheranostic Agents
Integration of biological macromolecules with inorganic materials via biomineralization has demon- strated great potential for development of nanotheranostic agents. To produce multifunctionality, integration of multiple components in the biomineralized …
Publication
Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats
Prenatal exposure to ozone has been linked to low birth weight in people and fetal growth restriction in rats. Clinical recommendations suggest use of low dose aspirin to lower risk of preeclampsia and intrauterine growth restriction in high-risk …
Publication
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
Dysregulation of Ca2+/calmodulin-dependent protein kinase (CaMK)II is closely linked with myocardial hypertrophy and heart failure. However, the mechanisms that regulate CaMKII activity are incompletely understood. Here we show that protein arginine …
Publication
Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure
Background: The extension of sepsis encompassing the preterm newborn’s brain is often overlooked due to technical challenges in this highly vulnerable population, yet it leads to substantial long-term neurodevelopmental disabilities. In this study, we …
Publication
Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy
The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca2+, chronically enhanced sympathetic tone with changed …
Publication
Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and mortality. Pathological LVH engages transcriptional programs including reactivation of canonical fetal genes and those inducing fibrosis. Histone lysine …
Publication
Clarifying the relative impacts of vascular and nerve injury that culminate in erectile dysfunction in a pilot study using a rat model of prostate irradiation and a thrombopoietin mimetic
PURPOSE: Radiation therapy (RT) offers an important and curative approach to treating prostate cancer but is associated with a high incidence of erectile dysfunction (ED). It is not clear if the etiology of radiation-induced ED (RI-ED) is driven by …
Publication
Utilizing Contrast-Enhanced Ultrasound Imaging for Evaluating Fatty Liver Disease Progression in Pre-clinical Mouse Models
We developed a protocol to investigate and optimize the application of contrast-enhanced ultrasound (CEUS) to non-invasive diagnosis of progressing fatty liver disease in mouse models. Eighteen 4-wk-old male C57 L/J mice were randomly assigned to one of …