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A novel role for miR-133a in centrally mediated activation of the renin-angiotensin system in congestive heart failure
Activated renin-angiotensin system (RAS) within the central nervous system has been implicated in sympathoexcitation during various disease conditions including congestive heart failure (CHF). In particular, activation of RAS in the paraventricular …
Publication
Cistanche deserticola ethanol extract attenuates left ventricular remodeling and dysfunction by reducing the inflammatory response after myocardial infarction
Objective: This study aimed to investigate whether Cistanche deserticola extract (CDE) exerted an inhibi- tory effect on the cardiac inflammatory response and prevented adverse remodeling after myocardial infarction (MI) in rats. Methods: Wistar rats were …
Publication
Echocardiographic Evaluation of Coronary Abnormalities and Cardiac Function in a Murine Model of Kawasaki Disease Using High-frequency Ultrasound
Background: Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD). This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine …
Publication
Danshen injection prevents heart failure by attenuating post-infarct remodeling
Danshen Injection (DSI) is a traditional Chinese medicine extracted from Danshen, prepared from the dried root and rhizome of Salvia miltiorrhiza Bunge. Danshen is an ancient antipyretic traditional Chinese medicine which is mostly used to improve blood …
Publication
Cardioprotection and lifespan extension by the natural polyamine spermidine
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and …
Publication
A Novel Murine Model of Marfan Syndrome Accelerates Aortopathy and Cardiomyopathy
Background. Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. Although significant advances in the understanding of …
Publication
Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression
Circular RNAs (circRNAs) have important roles in several cellular processes. No study has established the pathophysiological role for circRNAs in the heart. Here, we show that a circRNA (mitochondrial fission and apoptosis-related circRNA (MFACR)) …
Publication
Knockout of immunoproteasome subunit β2i ameliorates cardiac fibrosis and inflammation in DOCA/Salt hypertensive mice
The immunoproteasome is a multicatalytic protease complex in all eukaryotic cells, which plays a key role in regulating essential cellular processes. However, the role of immunoproteasome subunit b2i in regulation of cardiac fibrosis and inflammation in …
Publication
A humanized HLA-DR4 mouse model for autoimmune myocarditis
Myocarditis, the principal cause of dilated cardiomyopathy and heart failure in young adults, is associated with autoimmunity to human cardiac α-myosin (hCAM) and the DR4 allele of human major histocompatibility II (MHCII). We developed an hCAM-induced …
Publication
Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse
Obesity and diabetes are independent risk factors for heart failure and are associated with the consumption of diet rich in saturated fat and sugar, Western diet (WD), known to induce cardiac dysfunction in the mouse through incompletely characterized …