Here, acidic tumor microenvironment (TME)-responsive nano-Bi2 Se3 @MnCaP, as a near-infrared-II (NIR-II) biowindow-triggered free radical generator for hypoxia-irrelevant phototherapy, is elaborately developed by biomimetic mineralization of MnCaP onto 2, …

Protein tyrosine phosphatase receptor-f1 (PTPRZ1) is a transmembrane tyrosine phosphatase receptor highly expressed in em- bryonic stem cells. In the present work, gene expression analyses of Ptprz1?/? and Ptprz1þ / þ mice endothelial cells and hearts …

The histologically identifiable cellular struc- ture(s) involved in ultrasonic scattering is(are) yet to be uniquely identified. The study quantifies six possible cel- lular scattering parameters, namely, cell and nucleus radii and their respective cell …

Purpose: Accurate identification and assessment of sentinel lymph node (SLN) using noninvasive imag- ing methods can play a vital role in tumor staging, surgical planning, and prognostic evaluation. In this study, we assessed the efficacy of …

Shen Gui capsule (SGC) has been demonstrated to have a significant treatment effect for coronary heart disease (CHD). Nevertheless, the holistic therapeutic mechanism of SGC in vivo remain poorly interpreted. We aimed to systematically explore the …

Overweight/obesity is a growing pandemic nowadays that affects many organs and tis- sues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver …

Recombinant human growth hormone (rhGH), widely used in clinical studies, exerts protective effects against cardiac damage. Here, we investigated the effects and mechanisms underlying the effects of rhGH on cardiac functions in db/db mice. C57BL/6J and …

Objective: Myocardial infarction (MI) remains the leading cause of morbidity and mortality due partly to the limited regenerative capacity of cardiomyocytes to replace cardiomyocyte lost due to apoptosis. Inhibiting cardiomyocyte apoptosis is recognized …

Background G protein-coupled receptors (GPCRs) regulate the pathological and physiological functions of the heart. GPCR antagonists are widely used in the treatment of chronic heart failure. Despite therapeutic advances in the treatments for …

BackgroundDiabetes mellitus (DM) patients surviving myocardial infarction (MI) have substantially higher mortality due tothe more frequent development of subsequent pathological myocardial remodelling and concomitant functional deteriora-tion. This study …