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Acidic TME-Responsive Nano-Bi 2 Se 3 @ MnCaP as a NIR- II-Triggered Free Radical Generator for Hypoxia-Irrelevant Phototherapy with High Specificity and Immunogenicity
Here, acidic tumor microenvironment (TME)-responsive nano-Bi2 Se3 @MnCaP, as a near-infrared-II (NIR-II) biowindow-triggered free radical generator for hypoxia-irrelevant phototherapy, is elaborately developed by biomimetic mineralization of MnCaP onto 2, …
Publication
Integrative Cardiovascular Physiology and Pathophysiology Protein tyrosine phosphatase receptor- f 1 deletion triggers defective heart morphogenesis in mice and zebra fi sh
Protein tyrosine phosphatase receptor-f1 (PTPRZ1) is a transmembrane tyrosine phosphatase receptor highly expressed in em- bryonic stem cells. In the present work, gene expression analyses of Ptprz1?/? and Ptprz1þ / þ mice endothelial cells and hearts …
Publication
Ultrasound Scattering From Cell-Pellet Biophantoms and Ex Vivo Tumors Provides Insight Into the Cellular Structure Involved in Scattering
The histologically identifiable cellular struc- ture(s) involved in ultrasonic scattering is(are) yet to be uniquely identified. The study quantifies six possible cel- lular scattering parameters, namely, cell and nucleus radii and their respective cell …
Publication
Detection and Characterization of Sentinel Lymph Node by Ultrasound Molecular Imaging with B7 ‑ H3 ‑ Targeted Microbubbles in Orthotopic Breast Cancer Model in Mice
Purpose: Accurate identification and assessment of sentinel lymph node (SLN) using noninvasive imag- ing methods can play a vital role in tumor staging, surgical planning, and prognostic evaluation. In this study, we assessed the efficacy of …
Publication
Plasma metabolomics-based reveals the treatment mechanism of ShenGui capsule for application to coronary heart disease in a rat model
Shen Gui capsule (SGC) has been demonstrated to have a significant treatment effect for coronary heart disease (CHD). Nevertheless, the holistic therapeutic mechanism of SGC in vivo remain poorly interpreted. We aimed to systematically explore the …
Publication
Liver steatosis is a component of the hepatocardiorenal syn- drome provoked by a high-lipid diet and activation of Ang II pathways in rats
Overweight/obesity is a growing pandemic nowadays that affects many organs and tis- sues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver …
Publication
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy
Recombinant human growth hormone (rhGH), widely used in clinical studies, exerts protective effects against cardiac damage. Here, we investigated the effects and mechanisms underlying the effects of rhGH on cardiac functions in db/db mice. C57BL/6J and …
Publication
Overexpression of microRNA-135b-5p attenuates acute myocardial infarction injury through its anti-oxidant and anti-apptotic properties
Objective: Myocardial infarction (MI) remains the leading cause of morbidity and mortality due partly to the limited regenerative capacity of cardiomyocytes to replace cardiomyocyte lost due to apoptosis. Inhibiting cardiomyocyte apoptosis is recognized …
Publication
Corticotropin releasing hormone receptor 2 antagonist, RQ-00490721, for the prevention of pressure overload-induced cardiac dysfunction
Background G protein-coupled receptors (GPCRs) regulate the pathological and physiological functions of the heart. GPCR antagonists are widely used in the treatment of chronic heart failure. Despite therapeutic advances in the treatments for …
Publication
Exacerbated post‐infarct pathological myocardial remodelling in diabetes is associated with impaired autophagy and aggravated NLRP3 inflammasome activation
BackgroundDiabetes mellitus (DM) patients surviving myocardial infarction (MI) have substantially higher mortality due tothe more frequent development of subsequent pathological myocardial remodelling and concomitant functional deteriora-tion. This study …